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Dermatological Considerations in the Diagnosis and Treatment of Marginal Zone Lymphomas

Authors Ronchi A, Sica A, Vitiello P, Franco R

Received 5 January 2021

Accepted for publication 23 February 2021

Published 8 March 2021 Volume 2021:14 Pages 231—239

DOI https://doi.org/10.2147/CCID.S277667

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg


Andrea Ronchi,1 Antonello Sica,2 Paola Vitiello,3 Renato Franco1

1Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, 80138, Italy; 2Oncology and Haematology Unit, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, 80131, Italy; 3Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, 80131, Italy

Correspondence: Renato Franco
Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, Via Luciano Armanni 5, Naples, 80138, Italy
Tel +390815664084
Email [email protected]

Abstract: Primary cutaneous marginal zone lymphoma (PC-MZL) is a B-cell lymphoma arising in the skin. Although it is a rare disease, PC-MZL accounts for 20– 40% of all primary cutaneous B-cell lymphoma in Western Countries. The aetiology and the pathogenesis of PC-MZL are poorly understood, as it generally lacks the chromosomal translocations most typically present in marginal zone lymphomas of other sites. The diagnosis of PC-MZL may be challenging, due to the rarity of the disease, and needs the competence of different professional figures, including the dermatologist and the pathologist. Furthermore, the management of the patient after the diagnosis is complex and involves the dermatologist, the haematologist, the surgeon, the radiotherapist and the radiologist. The aim of this review is to describe the clinical and histological findings for the diagnosis of PC-MZL, and the state of art for the management of the patient.

Keywords: marginal zone lymphoma, cutaneous lymphoma, Borrelia burgdorferi, immunohistochemistry, dermoscopy

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