Back to Journals » Clinical Ophthalmology » Volume 7

Deposit buildup on prosthetic eye material (in vitro) and its effect on surface wettability

Authors Pine K, Sloan B, Han K, Swift S, Jacobs RJ

Received 24 November 2012

Accepted for publication 25 December 2012

Published 13 February 2013 Volume 2013:7 Pages 313—319


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Keith Raymond Pine,1 Brian Sloan,2 KyuYeon Ivy Han,1 Simon Swift,3 Robert John Jacobs1

1Department of Optometry and Vision Science, New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand; 2New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand; 3Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Auckland, New Zealand

Background: The aim of this in-vitro study was to investigate the effect of different polishing standards on prosthetic eye material (poly(methyl methacrylate) [PMMA]) on surface wettability and the rate of protein and lipid buildup.
Methods: Sample disks (12 mm diameter × 1 mm thickness) of PMMA were polished to three different standards of surface finish: low, normal, and optical quality contact lens standard. The sample disks were incubated in a protein-rich artificial tear solution (ATS) for the following periods of time: 1 second, 30 minutes, 1 hour, 4 hours, 24 hours, and 14 days. Surface wettability was measured with a goniometer before and after protein deposits were removed. One-way analysis of variance and paired-samples t-test were used for the statistical analysis.
Results: Between 13.64 and 62.88 µg of protein adhered to the sample disks immediately upon immersion in ATS. Sample disks with the highest polish attracted less protein deposits. The sample disks polished to optical quality contact lens standard were more wettable than those less highly polished, and wettability significantly decreased following removal of protein deposits. The addition of lipids to protein-only ATS made no difference to the amount of protein deposited on the sample disks for any of the standards of surface polish tested.
Conclusion: The findings are consistent with the results of the in-vivo investigation reported previously by the authors. Our view that the minimum standard of polish for prosthetic eyes should be optical quality contact lens standard and that deposits on PMMA prosthetic eyes improve the lubricating properties of the socket fluids has been reinforced by the results of this study.
Keywords: protein deposits, surface polish, PMMA

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other article by this author:

Deposit buildup on prosthetic eyes and implications for conjunctival inflammation and mucoid discharge

Pine KR, Sloan B, Jacobs RJ

Clinical Ophthalmology 2012, 6:1755-1762

Published Date: 31 October 2012

Readers of this article also read:

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010