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Degos-Like Lesions In Association With Connective Tissue Diseases: A Report Of Three Cases And Literature Review

Authors Stavorn T, Chanprapaph K

Received 6 September 2019

Accepted for publication 26 October 2019

Published 7 November 2019 Volume 2019:12 Pages 815—822


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg

Taptim Stavorn, Kumutnart Chanprapaph

Division of Dermatology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Correspondence: Kumutnart Chanprapaph
Division of Dermatology, Department of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchatewi, Bangkok 10400, Thailand
Tel +66 2 201 1141
Fax +66 2 201 1211

Abstract: Degos disease is characterized by atrophic porcelain-white papules with peripheral erythema. Degos-like lesions have been reported in association with several connective tissue diseases (CTDs), mostly systemic lupus erythematosus (SLE), and rarely in dermatomyositis and systemic sclerosis. Herein, we report three cases of Degos-like lesions in CTDs. Two cases had Degos-like lesions linked to dermatomyositis. Both cases presented with severe inflammatory myopathy without pathognomonic cutaneous signs for dermatomyositis and lacked myositis-specific autoantibodies. Our third case, to our knowledge, is the first case of Degos-like lesions in association with overlapping systemic sclerosis and SLE without major organ involvement. The clinical presentation and histopathology findings of our cases support that Degos-like lesions may not be a specific entity but can be considered as a unique clinical pattern expressed in patients with CTDs.

Keywords: degos-like lesions, degos disease, dermatomyositis, systemic sclerosis, systemic lupus erythematosus, connective tissue diseases

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