Back to Journals » Biologics: Targets and Therapy » Volume 4

Decreasing glioma recurrence through adjuvant cancer stem cell inhibition

Authors Neman J, Jandial R

Published 22 June 2010 Volume 2010:4 Pages 157—162


Review by Single anonymous peer review

Peer reviewer comments 2

Josh Neman, Rahul Jandial

Division of Neurosurgery, City of Hope National Cancer Center, Duarte, CA, USA

Abstract: Gliomas remain one of the most challenging solid organ tumors to treat and are marked clinically by invariable recurrence despite multimodal intervention (surgery, chemotherapy, radiation). This recurrence perhaps, is as a consequence of the failure to eradicate a tumor cell subpopulation, termed cancer stem cells. Isolating, characterizing, and understanding these tumor-initiating cells through cellular and molecular markers, along with genetic and epigenetic understanding will allow for selective targeting through therapeutic agents and holds promise for decreasing glioma recurrence.

Keywords: glioma, cancer stem cells, epigenetic

Creative Commons License © 2010 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.