Back to Archived Journals » International Journal of Interferon, Cytokine and Mediator Research » Volume 2

Cytokines and sympathy: the control of regulatory T cells

Authors Cone R, Bhowmick

Published 15 April 2010 Volume 2010:2 Pages 41—47


Review by Single anonymous peer review

Peer reviewer comments 2

Robert E Cone, Sourojit Bhowmick

Department of Immunology, Connecticut Lions Vascular Vision Center, University of Connecticut Health Center, Farmington, CT, USA

Abstract: To ensure protection from external invaders, mitigate collateral damage from immune reactions, and prevent immune system responses against self, the immune response is highly regulated by the sympathetic nervous system, cytokines, together with both adaptive and innate regulatory T cells. Moreover, the generation and function of adaptive and innate regulatory T cells is also under strong regulation by the sympathetic nervous system. Here we consider modulation of regulatory T cells by the sympathetic nervous system and cytokines that could lead to strategies for the enhancement of an immune response, or the prevention or mitigation of autoimmune diseases.

Keywords: immunoregulation, regulatory T cells, cytokines, sympathetic nervous system

Creative Commons License © 2010 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.