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Cytokines and sympathy: the control of regulatory T cells

Authors Cone R, Bhowmick

Published 15 April 2010 Volume 2010:2 Pages 41—47

DOI https://doi.org/10.2147/IJICMR.S6758

Review by Single-blind

Peer reviewer comments 2


Robert E Cone, Sourojit Bhowmick

Department of Immunology, Connecticut Lions Vascular Vision Center, University of Connecticut Health Center, Farmington, CT, USA

Abstract: To ensure protection from external invaders, mitigate collateral damage from immune reactions, and prevent immune system responses against self, the immune response is highly regulated by the sympathetic nervous system, cytokines, together with both adaptive and innate regulatory T cells. Moreover, the generation and function of adaptive and innate regulatory T cells is also under strong regulation by the sympathetic nervous system. Here we consider modulation of regulatory T cells by the sympathetic nervous system and cytokines that could lead to strategies for the enhancement of an immune response, or the prevention or mitigation of autoimmune diseases.
Keywords: immunoregulation, regulatory T cells, cytokines, sympathetic nervous system

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