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Current and emerging treatment options for uveal melanoma

Authors Pereira PR, Odashiro AN, Lim L, Miyamoto C, Blanco PL, Odashiro M, Maloney S, De Souza DF, Burnier Jr MN

Received 5 December 2012

Accepted for publication 24 December 2012

Published 22 August 2013 Volume 2013:7 Pages 1669—1682

DOI https://doi.org/10.2147/OPTH.S28863

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Patricia Rusa Pereira,1 Alexandre Nakao Odashiro,2 Li-Anne Lim,1 Cristina Miyamoto,1 Paula L Blanco,4 Macanori Odashiro,3 Shawn Maloney,1 Dominique F De Souza,1 Miguel N Burnier Jr1

1The Henry C Witelson Ocular Pathology Laboratory, McGill University, Montreal, QC, Canada; 2Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada; 3Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil; 4Department of Pathology and Laboratory Medicine, University of Ottawa, ON, Canada

Abstract: Uveal melanoma (UM) is the most common primary malignant intraocular tumor in adults, with a 10-year cumulative metastatic rate of 34%. The most common site of metastasis is the liver (95%). Unfortunately, the current treatment of metastatic UM is limited by the lack of effective systemic therapy. Options for the management of the primary intraocular tumor include radical surgery as well as conservative treatments in order to preserve visual acuity. For metastatic disease, several approaches have been described with no standard method. Nevertheless, median survival after liver metastasis is poor, being around 4–6 months, with a 1-year survival of 10%–15%. In this review, the authors summarize current and promising new treatments for UM.

Keywords: uveal melanoma, choroidal melanoma, eye, metastasis, treatment, therapy

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