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Critical appraisal of ophthalmic ketorolac in treatment of pain and inflammation following cataract surgery

Authors Reddy R, Kim S

Published 3 June 2011 Volume 2011:5 Pages 751—758

DOI https://doi.org/10.2147/OPTH.S7633

Review by Single-blind

Peer reviewer comments 2


Rahul Reddy, Stephen Jae Kim
Department of Ophthalmology, Vanderbilt University, Nashville, TN, USA

Background: The purpose of this review was to provide a critical appraisal of the literature supporting the efficacy of ophthalmic ketorolac (Acuvail®) in the treatment of pain and inflammation after cataract surgery.
Methods: Literature search and expert opinion of the authors.
Results: Recent studies indicate greater intraocular drug levels in the anterior chamber and iris-ciliary body after topical application of Acuvail in comparison with older formulations of ketorolac. A large randomized, multicenter, placebo-controlled study demonstrated significantly less inflammation and pain after cataract surgery using Acuvail.
Conclusion: Acuvail appears to be effective in reducing post-cataract surgery pain and inflammation.

Keywords: ketorolac tromethamine, Acuvail®, postsurgical, cystoid macular edema, nonsteroidal anti-inflammatory drugs

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