Costs of Air Pollution in California’s San Joaquin Valley: A Societal Perspective of the Burden of Asthma on Emergency Departments and Inpatient Care

Introduction

Compelling scientific literature has demonstrated the detrimental effects on human health of primary and secondary anthropogenic ambient air pollution: nitrogen dioxide (NO₂), particulate matter (PM_2.5), and ground-level ozone (O₃).^1–3 Children, adolescents, the elderly, and patients with cardiopulmonary diseases are particularly at risk of the deleterious effects of exposure to concentrations of criteria pollutants.^4,5

Periods of pollution exposure are associated with increased health burden related to respiratory inflammation and undermined lung function, which aggravates respiratory diseases such as asthma and leads to symptoms such as coughing, wheezing, or difficulty breathing.⁶ Furthermore, the US Environmental Protection Agency (EPA) has recognized that human exposure to air pollutants, such as particular matter and ground-level ozone, are likely causes of asthma and respiratory infections.⁷

In the US asthma costs $82 billion annually in healthcare costs, missed work, and school absences.⁸ In other developed countries respiratory diseases account for 52 million DALY losses per year, a conservatively estimated value of $317 billion in healthcare costs, lost productivity, and disability.⁹ By 2050, global health-related costs from ozone exposure will be estimated to reach $580 billion.¹⁰ In just one region of India, economic losses due to PM_2.5 pollution were valued at US$ 2.2 billion in 2013.¹¹ NO₂ has been deemed the “most harmful” of all nitrogen oxide compounds that humans are exposed to daily,¹² and the National Health Service (NHS) of England has estimated that by 2025, NO₂ will cost US$ 3.29 billion in healthcare and social costs for childhood asthma, coronary heart disease, stroke, and lung cancer.¹³

Current Evidence

The health and economic evidence of the impact of air pollution has been accumulating over time from studies worldwide. Existing research has examined the significant costs associated with exposure to particulate matter (PM) air pollution in France and Lebanon.^14,15 These studies accounted for 135 million francs in medical care, pharmaceuticals, x-rays, and labs for one million residents living near a power plant who suffered asthma exacerbations, bronchitis, and other respiratory conditions, as well as a range of US$ 2,700,000 to US$ 126,000,000 for people 40–59 years old and 20 years of productivity loss associated with pneumonia, COPD and ED visits related to PM.

In the context of fast-growing economies, estimations indicate that air pollution costs India the equivalent of 8.5% of its annual growth domestic product.¹⁶ A peer-review study attributed US$ 113.08 million to PM and US$ 218.1 million to NO₂ related adverse health outcomes such as bronchitis, asthma, and other acute respiratory symptoms in 13 months.¹⁷ In China, researchers estimated that excess deaths, premature mortality, hospital care, medicines, and outpatient visits for bronchitis and asthma related to PM_2.5 resulted in a welfare loss of US$ 126.6 billion and productivity losses in the range of US$ 12.5 to US$ 44.6 billion.¹⁸ Another study determined that PM_2.5 related asthma and acute and chronic bronchitis had a cost of US$ 55.01 billion in hospital care, outpatient visits, and labor income losses for 2013.¹⁹

In the United States, the focus has shifted towards transportation as a significant source of air pollution emissions and greenhouse gases.²⁰ Existing studies in LA County and Southern California, quantified the costs associated with air pollution, especially near-roadway air pollution (NRAP).^21,22 Their estimations included costs of US$ 441 million for ozone, and US$ 202 million for NO₂ related asthma exacerbations and bronchitis in children from hospital admissions, emergency department visits, medications, and caregiver lost wages. Researchers found that the costs of coronary heart disease hospitalizations, treatment, and mortality associated with PM_2.5 were US$ 16,751 million, and for NRAP as much as US$ 11,461 million.

The San Joaquin Valley Region

There is evidence that the San Joaquin Valley (SJV) region is overburdened by both air pollution and related ill health. California’s SJV is one of the most polluted regions in the US, exceeding state and national standards for ozone (O₃) and particulate matter (PM_2.5).^23–25 Recent studies have demonstrated that NO₂ has adverse impacts on asthma and respiratory symptoms for the region’s population despite meeting federal and state air quality standards.^26–28 Also, the region has the highest prevalence of asthma (17.6%) compared to the state’s prevalence (15.7%), Los Angeles (15.1%), and the Bay Area’s (16%).²⁹

In 2023, the American Lung Association gave every major city in the SJV a failing grade -F- in their “State of the Air” report for high ozone days, 24-hour particulate matter pollution, and annual particle pollution³⁰ asserting that Bakersfield in Kern County had replaced the city of Fresno in having the worst short-term particle pollution, and has the most year-round particle pollution along with Visalia in Tulare County. Regional environmental scholars found a positive association between ground-level ozone exposure and increased emergency department visits, especially in children 6–18 years old (OR: 1.219) and people of color (OR: 1.159).²⁴

California’s San Joaquin Valley (SJV) region is comprised of eight counties: Kern, Tulare, Kings, Fresno, Madera, Merced, Stanislaus, and San Joaquin. The region is the home of approximately 4.3 million residents,³¹ and it is situated at the midpoint between the San Francisco Bay Area and Los Angeles in Southern California,³² making transportation and distribution a considerable economic activity.³³ Other economic drivers in the region include agriculture, and oil and gas production.

The SJV is an air basin with arid and semi-arid geography. Meteorological conditions in the area have distinct seasonal characteristics and combined with its unique topography, confine pollution emitted by sources, and gusted from contiguous regions.³⁴ In recent years, the region has added wildfires and forest fires to the contributors of air pollutants in the region.^35–37

Despite existing conditions and knowledge, there is only one peer-reviewed study addressing the health burden and associated costs of air pollution specifically for the SJV region published in 2008.³⁸ Hall, Brajer & Lurmann measured the potential gains should the San Joaquin Valley region improve its air quality by estimating PM_2.5 and ozone health effects and costs for ED visits, hospital admissions, school absences, work loss days, and restricted activity days of asthma, bronchitis, respiratory symptoms, and premature mortality using epidemiological estimates from other locations. They concluded that ozone-attributed health costs are US$ 32.64 million per year, and US$ 3,206 million per year are attributed to PM_2.5 exposures; effectively $1000 per person in the Valley per year.

Aims and Research Questions

This study aims to analyze the economic impact of air pollution-related adverse respiratory health outcomes employing a societal perspective and cost-of-illness (COI) design.³⁹ Using a prevalence approach, this research estimated the burden of air pollution on asthma and upper respiratory infections (URIs) amongst SJV residents who attended the ED and were hospitalized in 2016. The research questions to be answered in this work were: i) what are the asthma and URI direct and indirect health costs of SJV residents exposed to higher concentrations of NO₂, PM_2.5, and O₃?, and ii) what are the effects of reducing pollution concentrations of O₃, NO_2, and PM_2.5 in the attributable cases of asthma and URI ED visits and hospitalizations?

Materials and Methods

To test the research questions, the study’s design included strengthening factors from past economic-based health projects: 1) A COI study is a prevailing method for valuing the economic burden of disease; 2) The human capital theory^40–42 is the leading approach used in COI or economic burden of disease studies; and 3) the study utilized a prevalence method^43,44 to estimate ED and hospitalization costs related to air pollution in 2016.

The year 2016 was selected for this study as the SJV experienced fewer forest fires and wildfires ex-ante and ex-post, and could be employed in comparative analyses to other periods with further air pollution risks, particularly during climate-change-related events.⁴⁵ Furthermore, after two congressional delays, 2016 was the first full year (12 months) of national ICD10 coding implementation which began on October 1, 2015⁴⁶ lessening execution uncertainty.

Exposure Assessment

The approach for assessing exposure in the SJV is derived from a regional epidemiological time-stratified case-crossover study²⁸ that examined the relationship between exposure to NO₂, O_3, and PM_2.5 and adverse health outcomes in asthma and upper respiratory infections using linked ED and hospitalization records as reported to the State of California Department of Health Care Access and Information (HCAI). The estimates describe the marginal effects of the associations between pollutant concentrations and adverse health outcomes that are the base for calculating population-attributable asthma outcomes. The health endpoints included in this study are shown in Table 1. For O₃, the pollution-related asthma and URI estimate selected was for the ED visits in the SJV for 2016, since the hospital admissions estimate was not statistically significant in the regional epidemiological analysis,²⁸ it was not included in this study.

Table 1 Health Endpoints

Air-Pollution Attributable Health Effects

Based on previous studies, the background levels of pollution selected were the interquartile ranges (IQR) for O₃ and NO₂ parts per billion measurements in the warm season and PM_2.5 per µg/m³ in the cold season. The pollutant-related effects for the exposed population (P_e) were calculated per marginal increases in the IQR concentration levels at the 75th percentile to the maximum of each pollutant in the concentration-response function (CRF).

Using the 2016 population estimates from the California Department of Finance,⁵¹ the proportion of exposed (P_e) was estimated for each SJV county. The attributable risk percent (AP) for case-control studies⁵² was estimated to demonstrate the burden of ED visits and hospitalizations that are attributed to each pollutant among the exposed.

To model the number of events that may be averted with marginal decreases of pollutant concentrations in the SJV, the population-attributable fraction (PAF) was calculated using the modeled background concentration-response of exposure effects for ED visits and hospitalization cases adjusted for seasonality. The formula correction was applied for case-control designs (see Equation 1).^53–55

(1)

The data from the California Health Interview Survey (CHIS) sources were used to identify the prevalence of asthma among people in the SJV. CHIS is a statewide health survey housed at the UCLA Center for Health Policy Research. The database was queried to gather estimated asthma rates by age of survey participants residing in the counties of the SJV.⁴⁹

The analysis to estimate the adjusted PAF⁵⁶ was conducted using STATA v.18.⁵⁷

Monetized Value of Air Pollution-Related Morbidity

Cost Typology

The typology of the direct, indirect, and intangible morbidity costs attributed to O₃, NO₂, and PM_2.5 pollution exposure is found in Figure 1. This approach accounts for a comprehensive estimate of healthcare and social costs attributed to ED visits and hospital admissions.

Figure 1 Cost typology for Asthma & URI ED visits and Hospitalizations.

Economic Valuation: Direct Costs

To monetize the air-pollution-related adverse health outcomes, the direct value attributed to ED and hospitalization cases was assessed using the 2016 Medicare Physician Fee Schedule and the Medicare Inpatient Hospitals Payments dataset from the Centers for Medicare and Medicaid Services (CMS).⁵⁸ The approach to determine the cost of ED visits included estimating the mean amount paid for each operating procedure code reported in all encounters included in the exposure assessment, see Equation 2.

(2)

The estimation of an economic value for each hospitalization was retrieved from HCAI linked patient discharge data which included diagnostic-related groups (DRGs) for asthma and URI events in 2016. A uniform price was calculated using the CMS average paid dataset available by geography. The use of CMS payments by DRGs and procedure codes restricted potential underestimations or overestimations caused by variability in charges by providers or payments by health insurers and reduced uncertainty. Because DRGs are based on a resource-based valuation approach^59–61 they more accurately reflect the value of the resources associated with treatments than payments by insurers. While DRGs characterize an improved measure of healthcare expenditures, the literature suggests that they may underestimate the costs to individuals (ie, out-of-pocket charges). Furthermore, research has found associations between the use of DRGs and shorter lengths of stays for inpatient stays which may be contradictory to the anticipated therapeutic benefits of medical interventions.^62–67

The cost of medications associated with asthma management therapeutics such as antibiotics, controllers, and rescue inhalers were obtained using data from the available literature and the publicly available data. Existing literature was used to identify the characteristics and recommended frequency of pharmaceutical use and duration,⁴⁷ such as clinical guidelines.

Market prices were used to estimate the cost of the treatments.⁶⁸ Undergoing this approach allowed a comprehensive inclusion of all healthcare related to an ED visit or hospitalization due to asthma exacerbations or upper respiratory infections.

Economic Valuation: Indirect and Opportunity Costs

The indirect costs for ED visits and hospitalizations due to air pollution-related asthma and URI exacerbations were the value of adult (18+ years of age) SJV resident cases’ time waiting and receiving care. For children 2–17 years old, the value of time included a parent or caretaker’s time waiting and caring for the patient. Indirect and intangible cost data, such as loss of workdays or productivity loss, and school absences were obtained through the exposure assessment patient discharge data, peer-reviewed literature,⁴⁸ and educational and labor agencies, such as the California Employment Development Department,⁶⁹ see Table 2.

Table 2 Economic Values

Furthermore, for ED visits, one workday was used as the time for missed school by children and a workday or productivity loss for the parent/caretaker and valued at the state reimbursement loss for the average daily attendance reimbursement⁷⁰ and average wage rate in California.⁷¹ For the population 65+ years of age, the opportunity cost for ED visits and hospitalizations was estimated to assess the value of time that could be spent doing other activities, the base of the calculation was average symptom days for ED visits obtained from the literature,⁵⁰ and the mean length of service days for 2016 hospitalizations. The economic value was retrieved from the Social Security Administration’s average retiree benefit amount in 2016.⁷²

Results

Estimates of attributable risk proportion (AR%) for asthma and URI ED visits and hospitalizations in 2016 from exposure to the three criteria pollutants included in this study are presented in Table 3 with lower and upper limits. The highest risk among the exposed is attributed to PM_2.5 in ED visits, and ground-level O₃ had the lowest risk. Because NO₂ was found to have higher odds of attending the ED and being hospitalized in the warm season of the SJV air basin, the risk for NO₂ is also higher in the exposed than the effects of exposure to O₃. The exponential odds ratio increases in IQR of each pollutant measured by federally regulated air monitors in 2016 are presented with 95% confidence intervals.

Table 3 Attributable Risk Proportion

Table 4 SJV Region Population Attributable Fraction

Table 5 SJV Population Exposed by County and Criteria Pollutant

Table 6 Emergency Department Events Attributed to Pollutant Background Levels

Table 7 Hospital Events Attributed to Pollutant Background Levels

Table 8 Health Effects per Marginal Reductions of Pollution Concentration

To evaluate the economic and public health impact of reducing the exposure to O₃, NO₂, and PM_2.5 in asthma and URI-related ED visits and hospital admissions, first, the population-attributable fractions were estimated for each pollutant at the IQR levels in each season of 2016. The SJV population exposed proportion and the adjusted population attributable fraction (PAF) for each pollutant in the study are shown in Table 4.

To illustrate the SJV population residents that were exposed to each criteria pollutant included in the study, using the available results from an epidemiological study for the region’s population,²⁸ the estimates are available in Table 5.

Health Outcome: Emergency Department Visits

The estimated number of ED visits attributable to exposure to background levels of O₃, NO₂, and PM_2.5 concentrations is in Table 6. The cases are categorized by age for children (2–17 years of age), adults (18–64 years old), and older adults (65 years and older). The classification of results in these age categories demonstrates the difference in health care and societal costs associated with waiting, caring for, receiving treatment, productivity loss, missed school, and opportunity costs. Hence, the monetized costs range from US$ 3,353 for adults 65 years and older, US$ 3,675 for working-age adults, to US$ 5,003 for school-age children per ED visit, where children’s asthma and URI monetization has a higher value because of the amount of time and resources that a parent or caretaker must spend with that child during symptoms days and treatment.

In 2016, the value to society for the cases of asthma and URI due to ground-level ozone was US$ 169,428,261. Of the total population of the SJV, which was 4,067,792 in 2016, 1,064,355 were children 2–17 years old, and asthma and URI cases attributed to ground-level ozone were 7,388. Working-age adults of the SJV had the largest proportion of the population, 2,522,151, and the number of cases attributed was 31,195. Adults 65 years and older were 481,286 in 2016 and accounted for 5,315 estimated cases of emergency department visits for asthma and URI attributed to ground-level ozone exposure. Estimates of NO₂ exposure effects on ED visit cases in children were 8,764 events, for working-age adults 37,004, and for older adults 6,305. The value of NO2 exposure-related ED events was US$ 200,978,032 for the SJV population. PM_2.5 healthcare costs and economic losses represented US$ 127,607,832, with a burden of 5,565 visits to the ED for children, 23,495 for adults 18–64 years old, and 4,003 for the elderly.

Health Outcome: Hospital Admissions

The exposure assessment did not find the association between O₃ exposure and hospitalization statistically significant; thus, it was not included in this study’s estimated population-attributable effects of outdoor pollutants. The estimated cases of NO₂ and PM_2.5, with lower and upper limits, attributed effects on hospital admissions are reported in Table 7.

Asthma exacerbations and URI hospital admissions estimate value range was US$ 2,584 per inpatient day for adults 65 years and older, US$ 2,676 for working-age adults, to US$ 3,023 per child. The mean length of service for 2016 hospital admissions was 6.3 days in the exposure assessment.

The estimated hospitalizations for children in the SJV attributable to NO₂ were 9,818 and 3,998 for PM_2.5 and a value of US$ 41,769,155. Working-age adults’ hospital admissions burden was 41,454 events for NO₂ and 16,879 for PM_2.5, and for the elderly NO₂ and PM_2.5 contributed to 7,063 and 2,876 cases respectively.

The estimated value to society for air pollution adverse health outcomes totaled US$ 498,014,124 in ED visits and US$ 223,552,720 in hospital admissions for the SJV population in 2016.

Modeling Exposure Reduction Effects on Health Outcomes

The population-attributable fraction (PAF) measures the proportion of cases in a population that can be attributed to an exposure and assists in evaluating the potential impact of reducing or eliminating the risk factor. The PAF was used to estimate the impact of marginal pollution concentration reduction of one unit measure in the cases of ED visits and hospitalizations for asthma exacerbations and URIs in the SJV population. Each outcome is valued in 2016 US$ and are presented in Table 8.

In the model for ground-level ozone, the decrease of 1 ppb in the background concentration of air quality would result in 2,079 fewer ED visits annually for children 2–17 years old, working-age adults, and adults 65 years and older. The total cost savings to society would be valued at US$ 8,024,505 in healthcare costs, productivity loss, school absences, and opportunity costs.

Reducing the concentrations of 1 ppb in the concentrations of NO₂ from the air that SJV residents breathe would save US$ 82,482,683 annually in 4,261 fewer asthma ED visits and hospitalizations for children, 17,998 for working adults, and 3,064 fewer ED visits and hospitalizations for older adults.

The concentration reduction of 1 µg/m³ of PM_2.5 would result in 7,785 ED visit cases averted for all ages and 5,937 hospital admissions for all SJV residents. The value of averting these adverse health outcomes was US$ 46,664,702.

Discussion

This is one of the first public health economics studies to estimate the healthcare and social costs of air pollution-associated asthma and upper respiratory infections (URIs). From the societal perspective and a prevalence approach, the estimated burden of exposures to O₃, NO₂, and PM_2.5 background pollutant concentrations in asthma exacerbations and URI ED visits, and hospital admissions was valued at US$ 721,566,844 for the year 2016 in healthcare costs, missed school, productivity losses of parents, caretakers, and working-age adults, and the opportunity costs for older adults. The estimated burden of ED events attributed to the studied criteria pollutants for the whole SJV population was 129,025, and hospital admissions attributed were 82,082. Modeling marginal reductions in pollutant concentrations resulted in averting 21,786 ED adverse events and 19,328 hospitalizations for asthma and URIs. Averting these air pollution-related health outcomes would save an estimated US$ 137,171,890 in health care and social costs.

In a study conducted for the region from 2008,³⁸ morbidity, in baseline years 2002–2004, was valued at US$ 32.64 million for ozone, and US$ 3.2 billion, in morbidity and mortality for PM_2.5. The number of morbidity cases attributed to ground-level ozone and PM_2.5 could have been underestimated due to the disease estimates extrapolated from non-SJV geographical areas and dissimilar periods. In addition, their study used the value of statistical life (VSL) to monetize premature mortality from exposure to PM_2.5 which is a health endpoint that this study did not include. Also, the findings in this research differ from the US$ 193 million calculated for hospitalizations in selected California hospitals from 2005–2007.⁷³ However, the methodology used in that study combined ED visits and hospitalizations into single events, despite the inclusion of additional health endpoints, and used linear proportional reductions to model the cost savings of hospitalizations when exposure to ground-level ozone and PM_2.5 is decreased. In contrast, to calculate the cases attributed to pollution exposure, this study accounts for ED visits and hospitalizations separately to avoid duplication and used ß-value estimates from a regional epidemiological study which have been adjusted for meteorological factors, temporality, and seasonality to the nonlinearity of pollutant chemistry.²⁸

The results of this study suggest the need for policies aimed at mitigating the harms of air pollution on the residents of the San Joaquin Valley, especially those with asthma. There are, in general, two approaches that can be adopted to mitigate the impacts of air pollution: masks and other types of air filtration systems that can remove the particles from the air, and societal-level policies that reduce the total amount of pollutants that get emitted.

The choice of policy measures must be evidence-based and cost-effective. Additionally, regulators, permitters, and public health agencies should comprehensively and continuously assess these public health strategies to ensure democratic, equitable, and systematic implementation in the SJV region, particularly for the most vulnerable and who are experiencing higher costs. This would also include evaluating the extent to which the public would be willing to pay for mitigation measures, whether they are formulated to prevent and control harm from air pollution or reduce the number of pollutants discharged into the air.

Future studies should use contingent valuation methods to explore the tradeoffs the public is willing to make and should include evaluating favorability for existing and potential air pollution control and mitigation strategies (ie, hybrid and electric vehicles concerns, information quality, directed costs, reduction of fireplaces, high-polluter regulation, zero-emissions zones, telecommuting, etc.) that have been implemented in the region and elsewhere to determine which ones are likely to be supported and result in behavior change.

One of the strengths of the study is the use of regional empirical health outcome data. Applying short-term concentration-response associations of an epidemiological study based on San Joaquin Valley (SJV) residents, the analysis modeled what the region may gain in averting adverse health outcomes and attendance to emergency departments (ED) and hospitalizations to receive treatment and care. Additionally, the use of CMS resource-based pricing utilizing DRGs reduces uncertainty compared to health economics studies that use provider charges or health insurance payments that do not reflect negotiated discounts by individual entities. Lastly, the stratification of age groups in the cost analysis is supported by evidence that children and the elderly are more susceptible to pollution exposure. Hence, children’s air pollution-related morbidity is not only costly in terms of health care but also resource-intense in social costs due to care, missed school, and productivity losses by parents and caretakers.

This study did not assess the quality and access to care for children, working adults, and the elderly in the SJV which could be of influence in the health endpoints included. It has been documented in the peer-reviewed literature that older adults are more likely to be underdiagnosed and undertreated during respiratory events, such as asthma.^74–76 If this phenomenon affected the SJV, during the period of the study, then it could have resulted in an undercount of health outcomes for this age group.

Another strength of this study is the use of concentration-response functions per interquartile range measurements proceeding from the regulatory monitoring system in the region and of the same year as the health endpoints. This differs substantially from other studies that use mean concentrations which include the lower and highest levels, as well as health values decades older than the baseline years they measured.

Studies of cost estimation are helpful to assist decision-makers in formulating cost-effective policies to accelerate change in the region. In the present policy conditions, the SJV pollution attainment standards of 8-hour O₃ and 24-hour PM_2.5 are in extreme non-attainment and non-attainment respectively. As the exposure assessment study and the related value in economic costs in this analysis reflect, NO₂ is associated with the highest healthcare and social costs despite being in criteria pollutant standard attainment status. Thus, this geographically remarkable air basin needs a swift and comprehensive public health approach to decarbonize its economy and mitigate the adverse health effects of anthropogenic air pollution.

Limitations

A limitation of this study is related to the lack of primary care data included in the exposure assessment which could have led to an underestimation of burden to the region’s residents and healthcare providers, and value estimates. Primary care data is difficult to access for research purposes and it could be a valuable effort to conduct a future exposure assessment study to study the association of major criteria pollutants conspicuous in the SJV and health outcomes.

Another limitation of the study is the restricted assessment of intangible costs for the elderly population similar to other studies in which days spent in the ED or hospitalized were valued as the opportunity costs of spending that time in other activities and attributed to the daily average social security retirement benefit. Monetizing the pain and suffering of people attending the ED or hospitalized for an asthma exacerbation is an underestimation of the costs of a social choice. Ostensibly, a best practice for health economists is to also evaluate the disutility of the health state changes to appropriately value pain and suffering attributed to the burden of toxic exposures or any illness.

Some economic studies have reflected on the appropriateness of using COI versus contingent valuation (CV) and willingness to pay or accept (WTP/WTA) methods to monetize the burden of diseases.^38,77–81 However, the limitations on inclusiveness of existing CV and WTP studies available for this type of regional study applied to a region where there is a majority-minority racial/ethnic composition, would further add to the limitations of this study. Evidently, health economics has a lot more to do to include population-representative samples in instruments meant for resources and datasets in public health economic evaluations, which add to our recommendations for future research.

Conclusion

Air pollution is known as a negative externality of economic activity. This study estimated the monetized burden of three criteria pollutants O₃, NO₂, and PM_2.5 in asthma exacerbations and upper respiratory infections emergency department visits, and hospitalizations for San Joaquin Valley (SJV) residents. This analysis is one of the first to utilize an association of exposure with a societal perspective and a prevalence approach to cost-of-illness studies to value the causal burden. What is notable is that the air pollution-related adverse health outcomes overburdening the SJV region, and its healthcare system, are broadly preventable.

Often recognized as one of the most polluted regions in the US, the SJV is at a juncture to protect public health by preventing adverse health outcomes associated with one of the main drivers of climate change, air pollution. From a health economics perspective, this study has furthered the evidence that air pollution is a negative externality that imposes substantial social, environmental, and healthcare costs on the region’s residents. This analysis also provides economic and health outcome evidence of the benefits of reducing air pollution in the geographically unique air basin of the SJV.

Since virtually every human activity produces air pollution, future research should focus on examining what air pollution control and mitigation measures would SJV residents support or oppose to inform public health agencies accountable for regulating air quality and encouraging behavior change to avoid ill health.