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Correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1

Authors Makino S, Tampo H, Arai Y, Obata H

Received 21 October 2013

Accepted for publication 7 November 2013

Published 3 January 2014 Volume 2014:8 Pages 165—168

DOI https://doi.org/10.2147/OPTH.S56327

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Shinji Makino, Hironobu Tampo, Yusuke Arai, Hiroto Obata

Department of Ophthalmology, Jichi Medical University, Shimotsuke, Tochigi, Japan

Abstract: To evaluate correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1 (NF1), we examined ten cases with NF1 using near-infrared reflectance imaging. Patients ranged in age from 4 to 39 years. The angle used for near-infrared reflectance imaging was 55°. We counted the total number of choroidal abnormalities in an area within a 55° angle centered on the fovea and the total number of Lisch nodules on the iris by slit-lamp examination. No positive correlation was found between the number of Lisch nodules and patient age (Spearman's rank correlation coefficient ρ=0.117, P=0.7414). Choroidal abnormalities tended to increase with age (ρ=0.6150), but this difference was not statistically significant (P=0.0650). A positive correlation was found between the number of choroidal abnormalities and Lisch nodules (ρ=0.783, P=0.0267). In conclusion, choroidal abnormalities tend to increase with patient age and are correlated with the number of Lisch nodules.

Keywords: neurofibromatosis type 1, near-infrared reflectance, choroidal abnormality, Lisch nodule, age

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