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Correlation of Cardiac and Liver Iron Level with T2*MRI and Vitamin D3 Serum Level in Patients with Thalassemia Major

Authors Shaykhbaygloo R, Moradabadi A, Taherahmadi H, Rafiei M, Lotfi F, Eghbali A

Received 13 August 2019

Accepted for publication 26 February 2020

Published 11 March 2020 Volume 2020:11 Pages 83—87

DOI https://doi.org/10.2147/JBM.S227012

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Martin H. Bluth


Roya Shaykhbaygloo,1 Alireza Moradabadi,2 Hassan Taherahmadi,1 Mohammad Rafiei,3 Fariborz Lotfi,1 Aziz Eghbali1

1Pediatric Department, Arak University of Medical Science, Arak, Iran; 2Hematology Department, Arak University of Medical Science, Arak, Iran; 3Biostatistics and Epidemiology Department, Arak University of Medical Science, Arak, Iran

Correspondence: Aziz Eghbali
Pediatric Department, Arak University of Medical Science, Basij Square, Arak, Iran
Tel +989 187982460
Email aziz_eghbali@yahoo.com

Introduction: Thalassemia is a hypochromic microcytic anemia, which is characterized by congenital disorders. In thalassemia patients, bone diseases are one of the causes of mortality. Our goal was to investigate the association between vitamin D deficiency and increased iron uptake by cardiac myocytes and hepatocytes.
Materials and Methods: Forty patients with thalassemia major were studied in Amir Kabir Hospital, Arak, Iran. The information obtained through clinical examination. Serum ferritin level was determined by ELISA and T2*MRI performed for measuring iron content in the heart and the liver.
Results: The average age of the patients was 23.8 ± 10.7 years. The mean T2*MRI values were 23.7 ± 7. The vitamin D3 level in 33 patients (82.5% cases) was less than 20 ng/dl, 2 patients (5%) in the range of 20– 30 ng/dl, and the others had above 30 ng/dl. Correlation between vitamin D and age was 0.611. Correlation coefficient between heart and liver T2*MRI with ferritin level in patients was 0.437 and 0.335, respectively.
Conclusion: Due to significant associations, the periodic measurement of vitamin D, as well as PTH, is recommended for patients with thalassemia major.

Keywords: thalassemia major, T2*MRI, cardiac and liver iron level, vitamin D3

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