Back to Journals » Journal of Blood Medicine » Volume 11

Correlation of Cardiac and Liver Iron Level with T2*MRI and Vitamin D3 Serum Level in Patients with Thalassemia Major

Authors Shaykhbaygloo R, Moradabadi A, Taherahmadi H, Rafiei M, Lotfi F, Eghbali A

Received 13 August 2019

Accepted for publication 26 February 2020

Published 11 March 2020 Volume 2020:11 Pages 83—87


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Martin H. Bluth

Roya Shaykhbaygloo,1 Alireza Moradabadi,2 Hassan Taherahmadi,1 Mohammad Rafiei,3 Fariborz Lotfi,1 Aziz Eghbali1

1Pediatric Department, Arak University of Medical Science, Arak, Iran; 2Hematology Department, Arak University of Medical Science, Arak, Iran; 3Biostatistics and Epidemiology Department, Arak University of Medical Science, Arak, Iran

Correspondence: Aziz Eghbali
Pediatric Department, Arak University of Medical Science, Basij Square, Arak, Iran
Tel +989 187982460

Introduction: Thalassemia is a hypochromic microcytic anemia, which is characterized by congenital disorders. In thalassemia patients, bone diseases are one of the causes of mortality. Our goal was to investigate the association between vitamin D deficiency and increased iron uptake by cardiac myocytes and hepatocytes.
Materials and Methods: Forty patients with thalassemia major were studied in Amir Kabir Hospital, Arak, Iran. The information obtained through clinical examination. Serum ferritin level was determined by ELISA and T2*MRI performed for measuring iron content in the heart and the liver.
Results: The average age of the patients was 23.8 ± 10.7 years. The mean T2*MRI values were 23.7 ± 7. The vitamin D3 level in 33 patients (82.5% cases) was less than 20 ng/dl, 2 patients (5%) in the range of 20– 30 ng/dl, and the others had above 30 ng/dl. Correlation between vitamin D and age was 0.611. Correlation coefficient between heart and liver T2*MRI with ferritin level in patients was 0.437 and 0.335, respectively.
Conclusion: Due to significant associations, the periodic measurement of vitamin D, as well as PTH, is recommended for patients with thalassemia major.

Keywords: thalassemia major, T2*MRI, cardiac and liver iron level, vitamin D3

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]