Correlation between optic nerve involvement and chronic obstructive pulmonary disease
Authors Mikaeili H, Yazdchi M, Solahaye Kahnamouii S, Sadeghi-Hokmabadi E, Mirnour R
Received 14 October 2014
Accepted for publication 10 December 2014
Published 9 February 2015 Volume 2015:9 Pages 271—275
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Scott Fraser
Haleh Mikaeili,1 Mohammad Yazdchi,2 Shiva Solahaye Kahnamouii,2 Elyar Sadeghi-Hokmabadi,2 Reshad Mirnour2
1Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Science, Tabriz, Iran; 2Neuroscience Research Center, Tabriz University of Medical Science, Tabriz, Iran
Background: Chronic obstructive pulmonary disease (COPD) is a major public health problem worldwide. The aim of this study was to evaluate the rate of optic neuropathy in COPD patients.
Methods: Forty patients diagnosed with COPD and 60 healthy subjects as control group enrolled. After examination by a pulmonary subspecialist, patients were ranked by Global initiative for chronic Obstructive Lung Disease (GOLD) criteria, and patients with zero grades on GOLD criteria were excluded. Visual evoked potential by checkerboard (raster background) method with a frequency of 2 Hz were done for all participants. P-values less than 0.05 were considered as significant.
Results: Fifty-five percent of COPD patients had visual evoked potential abnormalities. Mean P100 latency in both eyes was significantly longer in COPD patients. Average P100/N140 amplitude in both eyes were insignificantly higher in COPD.
Conclusion: Higher P100 latency in COPD patients shows demyelinating type of optic nerve involvement; however, further investigation in this area is needed.
Keywords: visual evoked potential, neuropathy, COPD
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]