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Corneal imaging and densitometry measurements in keratoconus patients to monitor disease progression and treatment outcomes after contact lens or Intacs treatment

Authors Alzahrani K, Cristian C, Harper S, Carley F, Brahma A, Morley D, Hillarby MC

Received 10 April 2018

Accepted for publication 29 May 2018

Published 4 September 2018 Volume 2018:12 Pages 1653—1658

DOI https://doi.org/10.2147/OPTH.S168865

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Khaled Alzahrani,1,2 Cristina Cristian,3 Sophie Harper,3 Fiona Carley,3 Arun Brahma,3 Debbie Morley,3 M Chantal Hillarby1

1Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, Manchester, UK; 2Ophthalmology Department, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia; 3Manchester Royal Eye Hospital, Manchester, UK

Aim: The aim of this study was to compare the pre- and posttreatment corneal densitometry and corneal thickness value of keratoconus (KCN) patients managed via contact lenses (CLs) or by both intrastromal corneal rings and contact lenses.
Patients and methods: This prospective study was performed at the Manchester Royal Eye Hospital, UK. Patients were recruited before treatment and followed up for 12 months. Data of corneal densitometry and corneal thickness were collected using the Oculus Pentacam at the pretreatment visit and posttreatment visit at 12 months.
Results: Corneal clarity significantly differs between both groups at pre treatment at zone 0–2 mm for the anterior layer (P=0.002). The same diversity is present at zone 2–6 mm for the anterior layer (P=0.003) and posterior layer (P=0.008). The corneal clarity diversity found was not statistically significant at 12 months post treatment (P>0.05). Corneal thickness was found to be statistically significantly different between pre treatment and post treatment for the CL group for central corneal thickness (CCT) and thinnest area (P=0.01 and P=0.02), respectively.
Discussion: This study shows that KCN management with Intacs was found to be effective in maintaining corneal clarity for a longer time than that with CL alone. On the other hand, corneal clarity reduces with disease progression in cases managed with CLs only. Analysis of Oculus Pentacam images provides an objective evaluation to monitor the corneal status after these different pathways of management.

Keywords: keratoconus, contact lenses, densitometry, Intacs, keratocyte, haze

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