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Corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia

Authors Badawi A

Received 23 May 2016

Accepted for publication 20 July 2016

Published 30 September 2016 Volume 2016:10 Pages 1891—1898

DOI https://doi.org/10.2147/OPTH.S113412

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 4

Editor who approved publication: Dr Scott Fraser


Amani E Badawi

Department of Ophthalmology, Mansoura University, Mansoura, Egypt

Purpose: The purpose of this study was to evaluate the effects of accelerated cross-linking (CXL) on corneal endothelium in keratoconus and postlaser-assisted in situ keratomileusis (LASIK) ectasia.
Design: This study is a prospective nonrandomized controlled study.
Setting: This study was conducted in Mansoura Ophthalmic Center (Mansoura University) and Al-Mostakbal Ophthalmic Center, Mansoura, Egypt.
Methods: In total, 40 eyes with progressive keratoconus and 10 eyes with postLASIK ectasia were subjected to an accelerated CXL (10 mW/cm2 for 9 minutes). Qualitative and quantitative analyses of the corneal endothelial cells were conducted before CXL and 3, 6, and 12 months after CXL by using a specular microscope (Tomy EM-3000).
Results: There was a significant reduction in endothelial cell count particularly at 3 and 6 months postCXL. In addition, the coefficient of variance was also statistically significantly higher at 3 and 6 months postoperatively than the preCXL value. There was a slight change in the percentage of hexagonal cells.
Conclusion: The use of accelerated CXL (10 mW/cm2 for 9 minutes) has a transient negative impact on endothelial cell density and/or endothelial morphology.

Keywords: keratoconus, postLASIK ectasia, accelerated cross-linking, corneal endothelium

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