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Coping, schemas, and cardiovascular risks – study protocol

Authors Slepecky M, Kotianova A , Prasko J , Majercak I, Gyorgyova E, Kotian M, Zatkova M , Tonhajzerova I, Chupacova M, Popelkova M

Received 10 August 2017

Accepted for publication 28 August 2017

Published 13 October 2017 Volume 2017:13 Pages 2599—2605

DOI https://doi.org/10.2147/NDT.S148837

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder



Milos Slepecky,1 Antonia Kotianova,1 Jan Prasko,2 Ivan Majercak,3 Erika Gyorgyova,4 Michal Kotian,1,5 Marta Zatkova,1 Ingrid Tonhajzerova,6,7 Michaela Chupacova,1,5 Marta Popelkova1

1Department of Psychology Sciences, Faculty of Social Science and Health Care, Constantine the Philosopher University in Nitra, Nitra, Slovak Republic; 2Department of Psychiatry, Faculty of Medicine and Dentistry, University Palacky Olomouc, University Hospital Olomouc, Olomouc, Czech Republic; 31st Department of Internal Medicine, Faculty of Medicine, Pavol Josef Safarik University in Košice, 4Internal Medicine and Cardiology Private Practice MUDr Ivan Majercak, Košice, 5Psychagogia, Liptovsky Mikulas, 6Department of Physiology, 7Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic

Abstract: The aim of this article is to describe the protocol of a trial focusing on the psychological, anthropometric, cardiac, and psychophysiological factors contributing to increased risk of cardiovascular diseases (CVDs). As background, the article provides a short overview of research literature linking personal traits, maladaptive schemas, and coping styles with CVDs through reactivity of the autonomic nervous system.

Keywords: early maladaptive schemas, coping styles, personality traits, dissociation, heart rate variability

Background

Cardiovascular diseases (CVDs) cover a range of illnesses related to the circulatory system, including ischemic heart disease (IHD) and cerebrovascular diseases. According to the Organisation for Economic Co-operation and Development (OECD) indicators (2015), CVD remains the leading cause of mortality accounting for nearly one-third (32.3%) of all deaths in 2013. The Slovak Republic had the highest IHD mortality rate in OECD countries. These results show the need to create a comprehensive approach for prevention and cure. The study INTER-HEART (from 52 countries, with 15,000 patients with acute myocardial infarction and 15,000 matched controls) showed that 90% of myocardial infarctions in the world could be prevented because they are the result of individuals’ lifestyle.1 Direct and indirect economic costs and significant deterioration in the quality of life are forcing us to find factors, which can prevent and influence morbidity and mortality. There is also a need for creating programs that can increase the detection of personality traits to cope with emotional burden and stress which can identify the risk factors in human behavior that lead to the onset of CVD.

Distressing situations during childhood or adulthood have been connected with improved CVD risk, although their precise contribution is unknown.24 In addition, acute psychological stress and feelings of tension and frustration are associated with increased risk of CVD.516 Similarly, the epidemiological studies showed that psychosocial issues are highly and separately related to the development of CVD.3,17 Recently, a meta-analysis of published and unpublished data in over 197,000 participants has shown that job stress is related with a slight, but regular, increased risk of coronary heart disease.16

Emotional distress stimulates sympathetic activity producing fluctuations in cardiovascular system – tachycardia, an increase in blood pressure, and relocation of blood flow.1820 The sympathetic hyperactivity accompanied by parasympathetic hypoactivity characterizes the potential pathological mechanism causing heightened risk of cardiovascular pathology and also contributes to depression and anxiety disorders.2124

The mean arterial blood pressure remains characteristically controlled within a relatively narrow range at rest and can increase or decrease “appropriately” according to psychological, emotional, or physical stress.20,25 Individuals with high baseline sympathetic activity might be at increased risk of hypertension if the “balance” between sympathetic and parasympathetic nervous system is dysregulated.18,26 Individuals displaying exaggerated cardiovascular reactivity to stress are at a higher risk of developing heart disease.18,27 The study by Lampert et al28 showed that total cumulative stress score and cumulative adverse life events were inversely associated with ultralow-frequency, very low-frequency (VLF), and low-frequency (LF) power and standard deviation of NN intervals.

There is a substantial amount of data connecting sympathetic nervous system hyperresponsivity to the development of hypertension.29,30 The studies in patients with borderline hypertension have shown an increased cardiac output, intermediated by increased beta-adrenergic activity and reduced parasympathetic stimulation of the heart.31 Elevation of blood pressure was associated with certain personality traits, such as anger and its suppression, and also with unexpected, unfortunate life events.32,33 Evidence about the relationship between these factors and hypertension also points to an autonomic nervous system (ANS) dysfunction.31,32

The ANS is highly adaptable and permits the organism to continue its balance when experiencing strain or stress.21 On the other hand, the lack of flexibility and a rigid ANS can lead to physical and psychological pathologies.24,3437 While various investigations indicate that exaggerated cardiovascular reactivity to stress is linked with cardiovascular complications,29,30 a recent study also referred to diminished cardiovascular reactivity as a risk factor for health complications.38

Whether cumulative stress, including adversarial life events, is related to decreased heart rate variability (HRV), a noninvasive assessment of autonomic status which reflects poor cardiovascular outcomes, is unknown. HRV could reflect central nervous system activity.3941 Reduced HRV appears to indicate decreased cardiac vagal tone and elevated sympathetic activity in anxious and depressive patients and would reflect a deficit in the flexibility of emotional and physiological mechanisms.35 Total cumulative stress and adverse life events are connected with reduced cardiac autonomic function as measured by HRV.28 The decreased HRV is associated with other CVD risk factors.42 Low HRV is linked with higher risk of the first cardiovascular incident in persons without known CVD.43

Psychological aspects and stressful life events play a role at the beginning of the metabolic syndrome associated with several diseases (eg obesity), which is the risk factor for CVD.44 It is supposed that higher body weight is associated with clinical CVDs even at moderate degrees as an independent risk factor.45,46 The pathophysiological mechanisms of cardiovascular dysfunction in obesity have not been fully understood yet, but autonomic cardiovascular dysregulation has been anticipated as a link connecting higher body weight and the increased prevalence of heart disease.47 Earlier studies using HRV methods to measure cardiovascular autonomic function have shown that obese persons have a significant decrease in parasympathetic activity and a significant elevation in sympathetic modulation of cardiac function, demonstrating a shift in the sympathovagal equilibrium towards sympathetic predominance.48,49

Preliminary study

We have finalized a small pre-pilot study to assess the feasibility of design and the appropriateness of the study protocol.50 We compared the psychological, psychophysiological, and anthropometric factors connected with life events, depressivity, and quality of life of the persons with the risk for the development of CVD and healthy controls. The patients with CVDs showed higher scores of life events and depression and lower quality of life than healthy controls. In healthy controls, a higher amount of life events significantly negatively correlated with high-frequency total power, a possible marker of parasympathetic tone, and the level of depression correlated with overweight. In patients with cardiovascular problems, the score of life events was not linked with the cardiovascular or anthropometric factors. The main limitation of this study was the number of probands, but the results suggest some potential mechanisms by which stress may exert adversarial effects on cardiovascular morbidity in healthy persons.

Study aims

The study aims to determine whether psychological variables are related to risk aspects for CVD, and if so, what is the relationship and how this relation is mediated.

Expected model

The possible complex relations are shown in Figure 1.

Figure 1 Complex model of influences between important factors leading to cardiovascular parameters risk for cardiovascular diseases.

Theoretical hypotheses

(1)

There is a relationship between psychological parameters and risk factors for CVDs.

(2)

Psychological parameters are related to psychophysiological parameters and their responses to mental and physical stress.

(3)

Psychological parameters are related to anthropometric parameters.

(4)

Psychological parameters are associated with cardiovascular parameters risk for CVDs.

(5)

Psychophysiological parameters are related to cardiovascular parameters risk for CVDs.

(6)

Anthropometric parameters are linked to cardiovascular parameters risk for CVDs.

(7)

There exists a model that explains the pathway among psychological, psychophysiological, and anthropometric parameters risk factors and cardiovascular parameters risk for CVDs.

Methods

A cross-sectional study will be conducted to collect data for the evaluation of the relationship between psychological characteristics and the early indicators of CVD.

Participants and study setting

The study recruited 200 healthy persons aged above 21 years taking no medication that can influence the ANS.

The probands will be evaluated under standard conditions from 8.00 to 13.00 hours in the outpatient cardiology clinic. During first 15 minutes, participants will be informed about the protocol, and informed consent will be obtained. This time will also allow the probands to adapt to the environment and to calm down. Following this, the cardiological, psychological, psychophysiological, and anthropometric measurements will be taken.

The study will follow the rules outlined in the study by Farsky:51 the room temperature should be 22 (±1°C), after 10-minute rest. The probands can have only simple breakfast, and smoking and coffee drinking are not allowed 6 hours before the assessment. Alcohol drinking is forbidden 10 hours before measurements. Probands should have enough sleep the night before measurement. During measurement, sleeping and speaking are not allowed. The room should be free from outside sounds.

Measurements

Questionnaires

The following questionnaires will be used in the study.

Young Schema Questionnaire (YSQ-S3)

YSQ-SF3 was developed by Young.52,53 Ninety items are rated on a 6-point Likert-type scale. As each subscale consists of 5 items, the score obtained on the subscales varies between 5 and 30. The questionnaire has 18 subscales grouped into 5 schema domains as follows: Rejection, Impaired autonomy and performance, Impaired limits, Other-directedness, Over-vigilance and inhibition. Psychometric assessment using this questionnaire has been done in several countries. In studies from Turkey, Cronbach’s α internal consistency coefficients of schema domains determined by higher-order factor analysis ranged between 0.53 and 0.81. Internal consistency of 17 of the 18 scales was sufficient (Cronbach’s α>0.70). Internal consistency of the scale “Entitlement/grandiosity” was 0.67.5456 The purpose of the ongoing study is to perform psychometric assessment in Slovakia using this questionnaire.

Young–Rygh Avoidance Questionnaire (YRAQ)

YRAQ is a 41-item questionnaire which assesses schema Avoidance.57 Individuals rate responses on a 6-point scale. The high total score indicates a general pattern of schema avoidance. The inventory is not schema-specific: an avoidant coping style is often a pervasive trait that can be utilized to avoid any scheme. The reliability coefficient obtained through splitting was 0.79 in an Iranian study.58

Young Compensation Inventory (YCI)

YCI is a 48-item questionnaire that assesses schema overcompensation. The inventory has adequate test–retest reliability59 and high internal consistency.60,61

Temperament and Character Inventory – Revised (TCI-R)

TCIR consists of 240 items.62 The questionnaire evaluates 4 temperamental and 3 character personality traits. Features of temperament include Novelty seeking, Harm avoidance, Reward dependence, and Persistence. Characteristic features include Self-directedness, Cooperativeness, and Self-transcendence.63 Czech percentile standards were created by Preiss and Klose.64

Dissociative Experiences Scale (DES)

DES describes 28 dissociative experiences. Patients mark a spot on a 10-cm line according to the frequency of symptoms they experience.65 Current modifications of the dissociation model have arrived at the difference between a dimensional, nonpathological type and a discontinuous, pathological class of dissociation, which can be recognized by a subgroup of 8 items of the DES, the DES-Taxon (DES-T).66 This subscale consists of 8 out of the 28 DES items (items 3, 5, 7, 8, 12, 13, 22, and 27).67 The Czech version of the scale is similar to the original version regarding its validity, test–retest reliability, and the factor structure.68

Type-D Scale (DS-14)

D-type personality is defined as an increased tendency to experience negative emotions (negative affectivity, NA) in connection to non-expressed emotions (social inhibition, SI).69 NA is connected with the tendency to experience negative emotions like anxiety, anger, hostility, irritability, and dysphoria. SI refers to the difficulties in emotion expression and discomfort in the social situations. Type D is considered to be a relatively stable personal characteristic.69 In 1998, Johan Denollet developed DS-14 questionnaire based on the items from Minnesota Multiphasic Personality Inventory and the items created specifically to determine D-type personality. Scale DS-14 consists of 14 items, 8 of them are related to NA and 6 to SI. On a sample of 400 people, the results confirmed that the scale was internally consistent (Cronbach’s α 0.89 [NA]; 0.82 [SI]) and stable over time (test–retest after 3 months: 0.78 [NA]; 0.87 [SI]).70 Slovak adaptation of the scale was made by Ďurka.71,72 Psychometric properties were good, with Cronbach’s α=0.89 and 0.86 for NA and SI, respectively.73

Demographic questionnaire (DD)

DD contains basic information such as sex, age, marital and partnership status, employment status, education, and pension status.The questionnaire was developed for requirements of this study.

Psychophysiological measure

Heart rate variability as a psychophysiological measure will be evaluated. The differences in the ANS activity, indexed by HRV, have been measured by the analytic system ProComp Infiniti which uses the power spectral analysis of the beat-to-beat time series and quantifies the HRV. HRV was assessed in 3 positions (first – 5 minutes supine; second – 5 minutes standing; third – 5 minutes supine), recording beat-to-beat interval during paced breathing by ECG sensor with UniGel electrodes snapped on and placed on the chest. Power spectra were computed by a fast Fourier transform system for 3 spectrum ranges: (1) VLF (0.0033–0.04 Hz), (2) LF (0.04–0.15 Hz), and (3) high-frequency (HF: 0.15–0.40 Hz) powers.7477 To examine heart rate, we used the microcomputer system ProComp Infiniti. The system allows the transmission of the ECG signal radio to the receiver connected to the PC. Information was processed by a software program Biograph Infinity (version 6) from Thought Technology.

Anthropometric characteristics

Basic anthropometric parameters will be measured: weight, height, hip size, waistline, waist/hip ratio, waist/height ratio, and whole-body dual-frequency segmental bio-impedance – muscle mass, fat stock, % body fat, segmental distribution of muscle and fat mass, and fat-free mass.

Cardiovascular parameters

Basic cardiovascular parameters – blood pressure (mmHg) and heart rate (bpm) – will be evaluated at rest and in response to the orthostatic test. Using arteriography (Medexpert arteriography), aortic pulse wave velocity (PWVA), central aortic pressure, and augmentation index (AIX) will be measured for assessment of the risk of atherosclerosis. In addition, the stiffness/elasticity of the arteries (PWVA, AIX) will be measured and ECG (detection of QTc interval in ms) will be examined for estimating cardiovascular risk.

Primary outcome measures

Primary outcome measures indicating the cardiovascular parameters risk for CVDs are the stiffness/elasticity of the arteries (PWVA, AIX), blood pressure, and QTc interval.

Data monitoring

The data will be collected continuously and immediately entered into an Excel table by the study researchers. All data will be double-checked monthly for accuracy, referring to the paper-based forms. The data will be protected following the completion of the examination of the last participant at the final time point.

All databases will be organized according to the unique participant ID number (assigned at the beginning of the study), ensuring that the databases are merged correctly.

Statistical analysis

Statistics will be calculated using statistical software SPSS 24.0 for Windows and GraphPad Prism (version 5.0; http://www.graphpad.com/prism/prism.htm). The following statistical measures will be calculated: descriptive statistics for the demographic data, mean scores, and character of data distribution. Demographic, anthropometric, physiological, and psychological data will be analyzed using column statistics. The Shapiro–Wilk W-test will be used to determine normal distribution of the demographic and clinical variables. Differences between scores or measures will be computed by t-tests or Mann–Whitney tests in alternative subgroups of data, one-way ANOVA, or Kruskal–Wallis test in more than 2 data categories, according to the type of data distribution. The Fisher’s exact tests and chi-square tests will be used for the categorical variables. Relationships between treatment outcome and other factors will be analyzed by Pearson or Spearman and partial correlations. For reduction of the multicollinearity, the regression analysis will be made. Differences will be considered significant if p-values are less than 0.05.

Ethical issues

The investigation will be performed in agreement with the latest version of the Declaration of Helsinki and the Guideline for Good Clinical Practice.78 The local ethical committee of the Faculty of Social Science and Health Care, Constantine the Philosopher University in Nitra approved the study. Written informed consent will be obtained from participants after the procedures are fully explained.

Trial status

Participants began to enter the trial in January 2017. Recruitment will continue until December 2017.

Timetable

(1)

Preparing phase: July 2016–November 2016

(2)

Recruitment of the patients, data collection and ongoing analyses of the results, and publishing of partial results: November 2016–July 2018

(3)

Analysis of the results and publishing: August 2018–December 2020.

Discussion

The results of the study can help in better understanding of the interface between psychological parameters, psychophysiological parameters, anthropometric characteristics, and cardiovascular parameters risk for CVDs in individuals who were not treated for CVDs yet. These results may help to find new diagnostic, preventive, and treatment approaches.

There are various limitations linked to the technical and human possibilities of the probands, researchers, planned methods, and devices. The first is the high number of questionnaires which the probands have to fulfill. The problem of concentration will rise with time. The plan is exchanged between working with “papers” and cardiological and anthropometric measurements. We offer the probands the possibility to look for the outcomes and write summaries of the most relevant results and also give them expert advice in cases of recognized risk factors.

Conclusion

This study could find the correlation between psychological parameters, psychophysiological parameters, anthropometric parameters, and cardiovascular parameters risk for CVDs in asymptomatic individuals and create a possible model of interactions between parameters. Especially, this study will give an insight into the influences of early maladaptive schemas, coping styles, and personality traits on the risk for CVD. These findings could influence the development of new psychological and lifestyle-changing strategies for the prevention of CVD.

Acknowledgment

This article was supported by the research grant VEGA no APVV-15-0502.

Disclosure

The authors report no conflicts of interest in this work.


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