Copeptin: a new predictor for severe obstructive sleep apnea
Authors Cinarka H, Kayhan S, Karatas M, Yavuz A, Gumus A, ├ľzyurt S, Cumhur C├╝re M, Sahin U
Received 12 January 2015
Accepted for publication 25 March 2015
Published 10 April 2015 Volume 2015:11 Pages 589—594
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 3
Editor who approved publication: Professor Garry Walsh
Halit Çinarka,1 Servet Kayhan,1 Mevlüt Karata┼č,1 Asiye Yavuz,1 Aziz Gümü┼č,1 Songül Özyurt,1 Medine Cumhur Cüre,2 Ünal ┼×ahin1
1Department of Chest Diseases, 2Department of Biochemistry, Recep Tayyip Erdo─čan University, Rize, Turkey
Introduction: Copeptin which is the C-terminal fragment of antidiuretic hormone (ADH), is a biomarker that has been reported to be increased in various cardiovascular disorders, cerebrovascular diseases and associated with prognosis. Patients with obstructive sleep apnea syndrome (OSAS) have a tendency to develop coronary and cerebral atherosclerotic diseases.
Objectives: The aim of the present study was to study copeptin levels in patients with obstructive sleep apnea and in a control group in order to determine whether copeptin could be used as a biomarker predicting the severity of OSAS and possible complications in this group.
Methods: A total of 116 patients with OSAS, diagnosed by polysomnography, and 27 controls were included in the study. Blood samples were collected after overnight fasting, and copeptin levels were measured with enzyme-linked immunosorbent assay.
Results: Copeptin levels were significantly higher in the OSAS group compared to control group (2,156±502; 1,845±500 pg/mL, respectively, P=0.004). Mean copeptin level of the patients having apnea-hypopnea index (AHI) ≥30 was significantly higher than that of the patients having AHI <30 (2,392±415; 2,017±500 pg/mL, respectively, P<0.001). A multivariate regression analysis showed that copeptin level, (hazard ratio: 1.58; 95% confidence interval: 1.09–2.30) was a predictor of severe OSAS (P=0.016). Copeptin levels showed significant positive correlation with AHI (r=0.32; P<0.001), desaturation index (r=0.23; P=0.012), arousal index (r=0.24; P=0.010) and CRP (r=0.26; P=0.011) respectively.
Conclusion: Copeptin levels are high in OSAS patients and copeptin is a potential marker for identifying patients with a high risk of early cardiovascular complications of OSAS. Copeptin has modest sensitivity (84%) for discriminating severe OSAS patients who are candidates for severe cardiovascular complications.
Keywords: copeptin, obstructive sleep apnea, predictor, inflammation
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