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Conventional and novel stem cell based therapies for androgenic alopecia

Authors Talavera-Adame D, Newman D, Newman N

Received 28 March 2017

Accepted for publication 16 May 2017

Published 31 August 2017 Volume 2017:10 Pages 11—19

DOI https://doi.org/10.2147/SCCAA.S138150

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 2

Editor who approved publication: Dr Bernard Binetruy

Video abstract presented by Dr Nathan Newman.

Views: 83

Dodanim Talavera-Adame,1 Daniella Newman,2 Nathan Newman1

1American Advanced Medical Corp. (Private Practice), Beverly Hills, CA, 2Western University of Health Sciences, Pomona, CA, USA

Abstract: The prevalence of androgenic alopecia (AGA) increases with age and it affects both men and women. Patients diagnosed with AGA may experience decreased quality of life, depression, and feel self-conscious. There are a variety of therapeutic options ranging from prescription drugs to non-prescription medications. Currently, AGA involves an annual global market revenue of US$4 billion and a growth rate of 1.8%, indicating a growing consumer market. Although natural and synthetic ingredients can promote hair growth and, therefore, be useful to treat AGA, some of them have important adverse effects and unknown mechanisms of action that limit their use and benefits. Biologic factors that include signaling from stem cells, dermal papilla cells, and platelet-rich plasma are some of the current therapeutic agents being studied for hair restoration with milder side effects. However, most of the mechanisms exerted by these factors in hair restoration are still being researched. In this review, we analyze the therapeutic agents that have been used for AGA and emphasize the potential of new therapies based on advances in stem cell technologies and regenerative medicine.

Keywords: stem cells, stem cell therapies, hair follicle, dermal papilla, androgenic alopecia, laser, hair regeneration

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