Back to Journals » Clinical Ophthalmology » Volume 6

Cone dysfunctions in retinitis pigmentosa with retinal nerve fiber layer thickening

Authors Sobaci G, Özge, Gundogan FC

Received 7 December 2011

Accepted for publication 28 December 2011

Published 23 March 2012 Volume 2012:6 Pages 473—478


Review by Single anonymous peer review

Peer reviewer comments 2

Güngör Sobaci, Gökhan Özge, Fatih Ç Gündoğan
Department of Ophthalmology, Gülhane Military Medical Academy and Medical School, Etlik, Ankara, Turkey

Purpose: To investigate whether or not thicker retinal nerve fiber layer (RNFL) in retinitis pigmentosa (RP) patients relates to functional abnormalities of the photoreceptors.
Methods: Optical coherence tomography-based RNFL thickness was measured by Stratus-3™ (Zeiss, Basel, Switzerland) optical coherence tomography and electroretinogram (ERG) recordings made using the RETI-port® system (Roland, Wiesbaden, Germany) in 27 patients with retinitis pigmentosa and in 30 healthy subjects.
Results: Photopic ERG b-wave amplitude, cone ERG b-wave latency, 30 Hz flicker amplitude, and 30 Hz flicker latency had significant correlations to the RNFL-temporal (r = —0.55, P = 0.004, r = 0.68, P = 0.001, r = —0.65, P = 0.001, and r = —0.52, P = 0.007, respectively). Eyes with thicker RNFL (ten eyes) differed significantly from those with thinner RNFL (eight eyes) regarding cone ERG b-wave latency values only (P = 0.001). 
Conclusion: Thicker RNFL in patients with retinitis pigmentosa may be associated with functional abnormality of the cone system.

Keywords: optical coherence tomography, electroretinography, photoreceptor, b-wave

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]