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Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair

Authors Su J, Cao L, Yu B, Song S, Liu X, Wang Z, Li M

Received 9 January 2012

Accepted for publication 17 February 2012

Published 21 May 2012 Volume 2012:7 Pages 2547—2555

DOI https://doi.org/10.2147/IJN.S29819

Review by Single-blind

Peer reviewer comments 4

Jiacan Su, Liehu Cao, Baoqing Yu, Shaojun Song, Xinwei Liu, Zhiwei Wang, Ming Li

Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China

Abstract: A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biological properties were investigated. The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400–500 µm, and exhibited a porosity of 76%. The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds. When the m-BPC scaffolds were implanted into bone defects of rabbit thighbone, histological evaluation confirmed that the m-BPC scaffolds exhibited excellent biocompatibility and osteoconductivity, and more effective osteogenesis than the polyamide scaffolds in vivo. The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

Keywords: mesoporous bioglass, polyamide, composite scaffolds, biocompatibility, bone repair

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