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Competing risk analysis of primary tracheal carcinoma based on SEER database

Authors Gao HX, He X, Du JF, Yang SH, Wang Y, Zhang JW, Zhao CN

Received 8 October 2018

Accepted for publication 17 December 2018

Published 24 January 2019 Volume 2019:11 Pages 1059—1065

DOI https://doi.org/10.2147/CMAR.S190124

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 3

Editor who approved publication: Dr Beicheng Sun


HongXiang Gao,1 Xuan He,1 JianFei Du,1 SanHu Yang,2 Yang Wang,1 JunWei Zhang,1 ChenNian Zhao1

1Department of Oncology, Chang’An Hospital, Xi’an, Shaanxi, China; 2Department of Thoracic Surgery, Tangdu Hospital, Xi’an, Shaanxi, China

Purpose: To analyze the prognostic factors of primary tracheal carcinoma.
Patients and methods: All patients of primary tracheal carcinoma were extracted from the Surveillance, Epidemiology, and End Results database during 1973–2015. The potential prognostic factors were analyzed by using the competing risk analysis of R statistical software.
Results: A total of 485 eligible patients were enrolled. The univariate analysis indicated that age, sex, diagnostic confirmation, extension, lymph node, metastasis, multiple primary tumors, primary site surgery, and lymph node dissection were statistically significant for the patients’ death due to tracheal tumor. The multivariate analysis indicated that age (P=0.0000, CI: 1.0255–1.0630), lymph node (P=0.0000, CI: 1.6031–3.4890), metastasis (P=0.0100, CI: 1.1342–2.5790), multiple primary tumors (P=0.0000, CI: 0.0276–0.1090), and primary site surgery (P=0.0001, CI: 0.3565–0.7110) were independent prognostic factors affecting survival, and there were significant differences in the stratification of each prognostic factors.
Conclusion: Age, lymph node, metastasis, multiple primary tumors, and primary site surgery were independent prognostic factors of primary tracheal carcinoma.

Keywords: primary tracheal carcinoma, SEER, prognostic factor, competing risk analysis


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