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Comment on: “Three-year follow-up of ranibizumab treatment of wet age-related macular degeneration: influence of baseline visual acuity and injection frequency on visual outcomes”

Authors Kaya A

Received 12 March 2016

Accepted for publication 15 March 2016

Published 18 April 2016 Volume 2016:10 Pages 695—696

DOI https://doi.org/10.2147/OPTH.S108314

Checked for plagiarism Yes

Editor who approved publication: Dr Scott Fraser

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Abdullah Kaya

Department of Ophthalmology, Anittepe Military Dispensary, Ankara, Turkey

I read the current article titled “Three-year follow-up of ranibizumab treatment of wet age-related macular degeneration: influence of baseline visual acuity and injection frequency on visual outcomes” by Razi et al,1 with great interest.

View the original article by Razi et al

Dear editor

I read the current article titled “Three-year follow-up of ranibizumab treatment of wet age-related macular degeneration: influence of baseline visual acuity and injection frequency on visual outcomes” by Razi et al,1 with great interest. Authors present outcomes of ranibizumab treatment of wet age related macular degeneration. I congratulate authors for this well organized study.

Major disadvantage of treatment with anti-VEGF drugs is the recurrence of wet age related macular degeneration. Monthly or bimonthly injection is needed in lots of patients. Changes in visual acuity (VA) at 1, 2 and 3 year were evaluated in this study. Considering recurrence, time between last injection and VA measurement is important. Pro re nata (PRN) treatment regimen was applied to patients in this study. This means that some patients could be treated 1 month before measurement at 1, 2 or 3 years and some patients could be treated more than 1 month before the measurement. Elongation of time interval may increase risk of recurrence and cause a lower measurement of VA. Thus, it would be better to include VA measurements that are taken 1 month after closest treatments to each year. VA was found to be positively correlated with injection frequency. Increase of injection frequency also increases possibility of last treatments of each year to be closer to the measurement.

Disclosure

The author reports no conflicts of interest in this communication.


Reference

1.

Razi F, Haq A, Tonne P, Logendran M. Three-year follow-up of ranibizumab treatment of wet age-related macular degeneration: influence of baseline visual acuity and injection frequency on visual outcomes. Clin Ophthalmol. 2016;10:313–319.

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