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Comment On: “Effectiveness of Combining Thoracic Paravertebral Nerve Block and Serratus Anterior Plane Block in Non-Intubated Spontaneous-Ventilation Video-Assisted Thoracoscopic Surgery: A Retrospective Case-Control Study” [Letter]

Authors M Sethuraman R ORCID logo, Arulmozhi S, Babu A

Received 1 September 2025

Accepted for publication 26 September 2025

Published 8 October 2025 Volume 2025:18 Pages 13907—13908

DOI https://doi.org/10.2147/JIR.S564530

Checked for plagiarism Yes

Editor who approved publication: Professor Ning Quan



Raghuraman M Sethuraman, Shanmugapriya Arulmozhi, Akash Babu

Department of Anesthesiology, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, India

Correspondence: Raghuraman M Sethuraman, Department of Anesthesiology, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, #7, Works Road, New Colony, Chromepet, Chennai, 600044, India, Email [email protected]


View the original paper by Dr Shi and colleagues


Dear editor

We read with interest the retrospective study that assessed the combination of the thoracic paravertebral block (TPVB) and the serratus anterior plane block (SAPB) in video-assisted thoracoscopic surgery (VATS), and would like to provide a few clarifications.

Shi et al concluded that the combination of TPVB and SAPB resulted in a significant reduction in opioid requirement and inflammatory markers when compared to these two blocks applied alone.1 However, adding these two blocks is unnecessary as the TPVB provides sensory coverage of the entire hemithorax and is therefore inclusive of sensory coverage of the anterolateral part of the hemithorax alone provided by the SAPB.2 A recently published study could not find any significant difference between the combination of TPVB and SAPB versus TPVB alone.3 Shi et al did not critically analyze these two referenced articles2,3 (reference numbers 24 and 27 of Shi et al1) and instead wrote some vague points on these two references.

Based on the above-mentioned concepts, the results of the current study raise a few questions. First, it is intriguing that the combination of two blocks resulted in significant differences when compared to TPVB alone. Second, it is highly questionable that the SAPB group performed better than the TPVB group despite the partial sensory coverage provided by the SAPB. Third, the inflammatory markers are not routinely performed in all the cases undergoing VATS, that too at various time intervals as specified. Hence, we are surprised that details of inflammatory markers of all the cases could be available to the authors during their retrospective analysis.

Data Sharing Statement

Data sharing is not applicable as no data was generated.

Author Contributions

RMS – Conceptualization, writing-original draft, reviewing and Editing, SA and AB – Conceptualization, writing-original draft. All authors have agreed on the journal to which this communication will be submitted; reviewed and agreed on all versions and the final version accepted for publication; and agree to take responsibility and be accountable for the contents of this communication.

Funding

No funding was received.

Disclosure

The authors have no potential conflict of interest to disclose. Generative artificial intelligence was not used in this communication.

References

1. Shi Z, Shao G, Zhang X, et al. Effectiveness of combining thoracic paravertebral nerve block and serratus anterior plane block in non-intubated spontaneous-ventilation video-assisted thoracoscopic surgery: a retrospective case-control study. J Inflamm Res. 2025;18:11125–11137. PMID: 40837007; PMCID: PMC12361353. doi:10.2147/JIR.S526948

2. Sethuraman RM. Combination of paravertebral block and serratus anterior plane block in video-assisted thoracic surgeries-comment. Eur J Cardiothorac Surg. 2023;64(1). doi:10.1093/ejcts/ezad257

3. Dusseaux MM, Grego V, Baste JM, et al. Paravertebral block combined with serratus anterior plane block after video-assisted thoracic surgery: a prospective randomized controlled trial. Eur J Cardiothorac Surg. 2023;64(1). doi:10.1093/ejcts/ezad170

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