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Combined eye gel containing sodium hyaluronate and xanthan gum for the treatment of the corneal epithelial defect after pterygium surgery

Authors Kocatürk T, Gençgönül A, Balica F, Özbağcivan M, Çakmak H

Received 28 March 2015

Accepted for publication 21 May 2015

Published 13 August 2015 Volume 2015:9 Pages 1463—1466

DOI https://doi.org/10.2147/OPTH.S85638

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Editor who approved publication: Dr Scott Fraser


Tolga Kocatürk,1 Ataman Gençgönül,2 Faruk Balica,1 Mehmet Özbağcivan,1 Harun Çakmak1

1Department of Ophthalmology, Faculty of Medicine, Adnan Menderes University, Aydin, 2Department of Ophthalmology, Mevki Military Hospital, Ankara, Turkey

Aim: The aim of this study is to compare the effectiveness of the ophthalmic gels containing hyaluronate, xanthan gum, and netilmycine with fusidic acid in terms of recovery periods of corneal epithelium in the patients who underwent pterygium surgery.
Methods: Patients who underwent pterygium surgery were separated into two groups. Forty patients in group 1 were given eye gel containing sodium hyaluronate, xanthan gum, and netilmycine, and 40 patients in group 2 were given one drop of eye gel containing fusidic acid. The patients in both groups were examined at the 12th, 24th, and 48th hours in the postoperative period by using slit-lamp technique. The subjective complaints of the patients such as pain and stinging, and the recovery periods of the corneal epithelial defect were evaluated comparatively by fluorescein staining.
Results: The mean ages were 26±8 years (range: 18–35) and 24±6 years (range: 18–33) in groups 1 and 2, respectively. The closure period of the corneal epithelial defect was observed as 24±8 hours (range: 16–42) and 36±12 hours (range: 18–48) in groups 1 and 2, respectively. The number of the patients suffering from subjective complaints such as pain and stinging in the first 12 hours was six and 29 in groups 1 and 2, respectively. The difference was significant both clinically and statistically (P=0.001).
Conclusion: Combined eye gel containing hyaluronate, xanthan gum, and netilmycine accelerates the recovery of corneal epithelial defect and reduces the complaints of the patients, when compared to the fusidic acid gel. Combined eye gel should be considered as an option for the treatment of the corneal epithelial defect related with pterygium surgery.

Keywords: iatrogenic corneal epithelial defect, netilmycine, fusidic acid, ophthalmic gel

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