Back to Journals » International Journal of Nanomedicine » Volume 9 » Issue 1

Cognitive deficits and decreased locomotor activity induced by single-walled carbon nanotubes and neuroprotective effects of ascorbic acid

Authors Liu X, Zhang Y, Li J, Wang D, Wu Y, Li Y, Lu Z, Yu S, Li R, Yang X

Received 21 October 2013

Accepted for publication 28 November 2013

Published 11 February 2014 Volume 2014:9(1) Pages 823—839

DOI https://doi.org/10.2147/IJN.S56339

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Xudong Liu,1,* Yuchao Zhang,1,* Jinquan Li,1 Dong Wang,1 Yang Wu,1 Yan Li,2 Zhisong Lu,3 Samuel CT Yu,4 Rui Li,1 Xu Yang1

1Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan, People's Republic of China; 2Chemical and Biomolecular Engineering Department, Hong Kong University of Science and Technology, Hong Kong Special Administrative Region; 3Institute for Clean Energy and Advanced Materials, Southwest University, Chongqing, People's Republic of China; 4Division of Environment, Hong Kong University of Science and Technology, Hong Kong Special Administrative Region

*These authors contributed equally to this work

Abstract: Single-walled carbon nanotubes (SWCNTs) have shown increasing promise in the field of biomedicine, especially in applications related to the nervous system. However, there are limited studies available on the neurotoxicity of SWCNTs used in vivo. In this study, neurobehavioral changes caused by SWCNTs in mice and oxidative stress were investigated. The results of ethological analysis (Morris water maze and open-field test), brain histopathological examination, and assessments of oxidative stress (reactive oxygen species [ROS], malondialdehyde [MDA], and glutathione [GSH]), inflammation (nuclear factor κB, tumor necrosis factor a, interleukin-1β), and apoptosis (cysteine-aspartic acid protease 3) in brains showed that 6.25 and 12.50 mg/kg/day SWCNTs in mice could induce cognitive deficits and decreased locomotor activity, brain histopathological alterations, and increased levels of oxidative stress, inflammation, and apoptosis in mouse brains; however, 3.125 mg/kg/day SWCNTs had zero or minor adverse effects in mice, and these effects were blocked by concurrent administration of ascorbic acid. Down-regulation of oxidative stress, inflammation, and apoptosis were proposed to explain the neuroprotective effects of ascorbic acid. This work suggests SWCNTs could induce cognitive deficits and decreased locomotor activity, and provides a strategy to avoid the adverse effects.

Keywords: behavioral changes, oxidative stress, inflammation, apoptosis

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other article by this author:

Intraperitoneal injection of magnetic Fe3O4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice

Ma P, Luo Q, Chen J, Gan Y, Du J, Ding S, Xi Z, Yang X

International Journal of Nanomedicine 2012, 7:4809-4818

Published Date: 5 September 2012

Readers of this article also read:

Case-control association study of ABCB1 gene and major depressive disorder in a local Chinese Han population

Xie WW, Zhang L, Wu RR, Yu Y, Zhao JP, Li LH

Neuropsychiatric Disease and Treatment 2015, 11:1967-1971

Published Date: 4 August 2015

Focus group reflections on the current and future state of cognitive assessment tools in geriatric health care

Whitehead JC, Gambino SA, Richter JD, Ryan JD

Neuropsychiatric Disease and Treatment 2015, 11:1455-1466

Published Date: 12 June 2015

Factors associated with poor discharge status in patients with status epilepticus at Khon Kaen hospital

Chiewthanakul P, Noppaklao P, Sawanyawisuth K, Tiamkao S

Neuropsychiatric Disease and Treatment 2015, 11:1097-1101

Published Date: 20 April 2015

Predictors of remission in the treatment of major depressive disorder: real-world evidence from a 6-month prospective observational study

Novick D, Hong J, Montgomery W, Dueñas H, Gado M, Haro JM

Neuropsychiatric Disease and Treatment 2015, 11:197-205

Published Date: 22 January 2015

Cerebellar cryptococcosis characterized by a space-occupying lesion in an immunocompetent non-HIV patient

Liu BX, Dai XJ, Liu H, Gong HH, Wang YX, Zhang LL

Neuropsychiatric Disease and Treatment 2015, 11:21-24

Published Date: 19 December 2014

Anacardic acid enhances the anticancer activity of liposomal mitoxantrone towards melanoma cell lines – in vitro studies

Legut M, Lipka D, Filipczak N, Piwoni A, Kozubek A, Gubernator J

International Journal of Nanomedicine 2014, 9:653-668

Published Date: 23 January 2014

Embedded nanomicro syringe on chip for molecular therapy

Jalil MA, Suwanpayak N, Kulsirirat K, Suttirak S, Ali J, Yupapin PP

International Journal of Nanomedicine 2011, 6:2925-2932

Published Date: 18 November 2011