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Coexisting multiple myeloma, lymphoma, and non-small cell lung cancer: a case report and review of the literature

Authors Khade P, Devarakonda S

Received 31 July 2017

Accepted for publication 29 September 2017

Published 8 November 2017 Volume 2017:10 Pages 373—376

DOI https://doi.org/10.2147/IMCRJ.S147266

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Ronald Prineas

Parth Khade, Srinivas Devarakonda

Department of Internal Medicine, Louisiana State University Health, Shreveport, LA, USA

Abstract: Multiple myeloma is a plasma cell dyscrasia characterized by neoplastic proliferation of plasma cells, producing a monoclonal immunoglobulin. Small lymphocytic lymphoma (SLL) is a neoplasm consisting of monoclonal B-cell lymphocyte proliferation. We present an extremely rare case of coexisting multiple myeloma, SLL, and squamous cell carcinoma of the lung in a 74-year-old female patient. She initially presented with a midline mass with pain in the lumbar area. Debulking surgery was performed, and pathology showed plasmacytoma. Further evaluation revealed coexistent IgG kappa myeloma. Imaging revealed extensive abdominal lymphadenopathy, and mesenteric lymph node biopsy confirmed the presence of SLL. The patient was also found to have a mass in the left lower lobe of the lung; biopsy showed squamous cell carcinoma. This patient was treated with lenalidomide and dexamethasone for multiple myeloma, and stereotactic body radiotherapy for limited stage lung cancer. Due to the more indolent course of SLL, watchful waiting was applied.

Keywords: coexisting, multiple myeloma, lung cancer, non-Hodgkin’s lymphoma

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