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Clinical utility and patient considerations in the use of the sitagliptin-metformin combination in Chinese patients

Authors Du Q, Wang Y, Yang S, Han P

Received 14 November 2014

Accepted for publication 12 January 2015

Published 9 February 2015 Volume 2015:9 Pages 281—287

DOI https://doi.org/10.2147/PPA.S64691

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Naifeng Liu

Qiang Du, Yan-Jun Wang, Sheng Yang, Ping Han

Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China

Abstract: The prevalence of diabetes mellitus (DM) continues to increase each year. However, the efficacy of glucose-lowering therapies remains unsatisfactory. Moreover, the clinical characteristics and manifestations of DM in Chinese patients are different from those in Western patients. Thus, it is imperative to develop an optimal treatment protocol for lowering blood glucose levels in Chinese patients with DM. Sitagliptin has been used in People’s Republic of China, and sitagliptin and metformin combination therapy may not alter their individual pharmacokinetics. To date, several clinical trials undertaken to investigate the efficacy of sitagliptin and metformin combination therapy have revealed that it effectively controlled glycated hemoglobin, fasting plasma glucose, and postprandial plasma glucose levels to a greater extent than sitagliptin or metformin alone. In addition, the combined therapy was well tolerated and induced few side effects, which were largely mild. Furthermore, the combined therapy was easy to administer, and the patients receiving this therapy showed good compliance. Therefore, for Chinese patients with type 2 DM, sitagliptin and metformin combination therapy is preferred.

Keywords: type 2 diabetes mellitus, sitagliptin, metformin

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