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Clinical Significance of Factor XIII Activity and Monocyte-Derived Microparticles in Cancer Patients

Authors Sawai Y, Yamanaka Y, Nomura S

Received 29 November 2019

Accepted for publication 1 March 2020

Published 1 April 2020 Volume 2020:16 Pages 103—110

DOI https://doi.org/10.2147/VHRM.S240500

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Harry Struijker-Boudier


Yusuke Sawai, Yuta Yamanaka, Shosaku Nomura

First Department of Internal Medicine, Kansai Medical University, Osaka, Japan

Correspondence: Shosaku Nomura
First Department of Internal Medicine, Kansai Medical University, 2-3-1 Shin-Machi, Hirakata Osaka 573-1191, Japan
Tel + 81 72 804 2754
Fax + 81 72 804 2041
Email nomurash@hirakata.kmu.ac.jp

Background: The aim was to evaluate factor XIII activity (FXIIIa) and monocyte-derived microparticles (MDMPs) in cancer patients.
Methods: In total, 138 cancer patients (31 malignant lymphomas, 39 multiple myelomas, and 68 lung cancers) were analyzed. We measured various biomarkers including FXIIIa and MDMPs.
Results: The values of endothelial activation markers, monocyte chemoattractant peptide (MCP)-1, soluble (s)CD14, and MDMPs were higher in cancer patients than in non-cancerous controls. MCP-1, sCD14, and MDMPs were significantly correlated with FXIIIa in multivariate analysis in cancer patients. In addition, MCP-1, sCD14, and MDMP levels were significantly increased in the high FXIIIa group of patients. Finally, the survival rate of the high FXIIIa group was significantly poor in the Kaplan–Meier analysis.
Conclusion: These results suggest that abnormal levels of FXIIIa and MDMPs may offer promise as poor prognostic factors in cancer patients.

Keywords: factor XIII activity, cancer, thrombosis, endothelial cell, monocyte-derived microparticle, MDMP


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