Ciclesonide in persistent asthma: the evidence of its therapeutic value
Authors Kenreigh C, Wagner L, Chrisp P
Published 30 June 2006 Volume 2006:1-Issues 3 & 4(4)
Charlotte A. Kenreigh, Linda Timm Wagner, Paul Chrisp
MLC Solutions Ltd, Galena, Ohio, USA, and Core Medical Publishing, Knutsford, UK
Introduction: Asthma, a respiratory disease associated with airway inflammation and hyperresponsiveness, is one of the most prevalent chronic diseases worldwide affecting both children and adults. Inhaled corticosteroids are considered to be the cornerstone of asthma management. Ciclesonide, an airway-activated inhaled corticosteroid, has been developed for the management of persistent asthma. Its once-daily administration and airway activation may be advantageous in the treatment of asthma.
Aims: The purpose of this article is to review the place in therapy of ciclesonide in the management of patients with persistent asthma based on the available clinical evidence.
Evidence review: The available evidence indicates that ciclesonide has an effect on pulmonary function (forced expiratory volume in 1 s, forced vital capacity, and peak expiratory flow), as well as producing improvements in patient-reported symptoms that are equivalent to those achieved with other inhaled corticosteroids. A few studies have focused on health-related quality of life and have demonstrated a positive effect with ciclesonide treatment. Its pharmacokinetic profile may offer advantages in terms of adverse effects, both local and systemic, although most of the data come from 12-week studies.
Place in therapy: The current evidence shows that ciclesonide offers another alternative among inhaled corticosteroids, with the potential for fewer adverse effects. The unique pharmacokinetic profile of ciclesonide allows once-daily administration and the airway activation of the drug appears to confer clinical benefit in the treatment of asthma. Its lack of systemic adverse effects make it a viable option for pediatric use.
Key words: antiinflammatory, asthma, ciclesonide, evidence, inhaled corticosteroids, outcomes
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