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Chemotherapy-associated paronychia treated with a dilute povidone-iodine/dimethylsulfoxide preparation

Authors Capriotti K, Capriotti J

Received 15 June 2015

Accepted for publication 20 August 2015

Published 21 September 2015 Volume 2015:8 Pages 489—491

DOI https://doi.org/10.2147/CCID.S90542

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ram Prasad

Peer reviewer comments 3

Editor who approved publication: Dr Jeffrey Weinberg

Kara Capriotti,1,2 Joseph A Capriotti1,3

1ALC Therapeutics, LLC, Springhouse, PA, 2Bryn Mawr Skin and Cancer Institute, Rosemont, PA, 3Plessen Ophthalmology Consultants, Christiansted, VI, USA

Background: Nail changes associated with chemotherapy in general, and particularly with taxane and epidermal growth factor receptor inhibitor-based regimens, are common presentations in our clinical population. Currently, there are no consensuses about therapies supported by clinical trials nor are there any US Food and Drug Administration-approved treatments for this indication.
Findings: A 42-year-old woman with stage 2A breast cancer presented to our clinic with chemotherapy-induced paronychia. Symptoms were severe enough that cessation of chemotherapy was being considered. The patient's chemotherapy regimen included doxorubicin, cyclophosphamide, and docetaxel.
Conclusion: The topical povidone-iodine/dimethylsulfoxide system is very effective in alleviating the signs and symptoms of severe paronychia associated with chemotherapy. This novel combination warrants further investigation in randomized, controlled trials to further elucidate its clinical utility.

Keywords: paronychia, chemotherapy, breast cancer, povidone-iodine, dimethylsulfoxide

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