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Changes in choroidal thickness and volume are related to urinary albumin excretion in type 2 diabetic patients without retinopathy

Authors Farias LB, Lavinsky D, Benfica CZ, da Silva MO, Lavinsky J, Canani LH

Received 31 January 2018

Accepted for publication 22 March 2018

Published 10 August 2018 Volume 2018:12 Pages 1405—1411


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

Lucas Brandolt Farias,1,2 Daniel Lavinsky,1,2 Camila Zanella Benfica,1,2 Monica Oliveira da Silva,1,2 Jacó Lavisnky,1,2 Luis Henrique Canani2,3

1Department of Ophthalmology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; 2Ophthalmology Section, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; 3Department of Endocrinology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil

Purpose: To evaluate choroidal thickness and volume in patients with type 2 diabetes and microalbuminuria using spectral-domain optical coherence tomography.
Methods: We recruited 37 diabetic patients without diabetic retinopathy (18 normoalbuminuric and 19 microalbuminuric) and 21 healthy controls. Choroidal thickness and volume were mapped using the automated Early Treatment Diabetic Retinopathy Study grid and a topographic map of thickness was generated manually. Choroid was also measured at 10 locations under the fovea, temporally and nasally.
Results: Mean choroidal thickness and volume among patients with diabetes and microalbuminuria was reduced in all locations compared to controls (P<0.05). A sectoral decrease of choroidal thickness and volume was shown between microalbuminuric and normoalbuminuric groups.
Conclusion: Choroidal changes were present in type 2 diabetic patients before clinical development of retinopathy. Microalbuminuria was associated with a decrease in choroidal thickness and volume in diabetic patients without diabetic retinopathy.

Keywords: choroidal thickness, type 2 diabetes, microalbuminuria, optical coherence tomography

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