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Cerium oxide nanoparticles: green synthesis and biological applications

Authors Charbgoo F, Ahmad MB, Darroudi M

Received 17 October 2016

Accepted for publication 12 November 2016

Published 20 February 2017 Volume 2017:12 Pages 1401—1413

DOI https://doi.org/10.2147/IJN.S124855

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Thomas Webster


Fahimeh Charbgoo,1 Mansor Bin Ahmad,2,* Majid Darroudi3,*

1Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; 2Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 3Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

*These authors contributed equally to this work

Abstract: CeO2 nanoparticles (NPs) have shown promising approaches as therapeutic agents in biology and medical sciences. The physicochemical properties of CeO2-NPs, such as size, agglomeration status in liquid, and surface charge, play important roles in the ultimate interactions of the NP with target cells. Recently, CeO2-NPs have been synthesized through several bio-directed methods applying natural and organic matrices as stabilizing agents in order to prepare biocompatible CeO2-NPs, thereby solving the challenges regarding safety, and providing the appropriate situation for their effective use in biomedicine. This review discusses the different green strategies for CeO2-NPs synthesis, their advantages and challenges that are to be overcome. In addition, this review focuses on recent progress in the potential application of CeO2-NPs in biological and medical fields. Exploiting biocompatible CeO2-NPs may improve outcomes profoundly with the promise of effective neurodegenerative therapy and multiple applications in nanobiotechnology.

Keywords: cerium oxide nanoparticles, green synthesis, biocompatibility, surface Ce3+, size, morphology

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