Can Serum Nutritional Related Biomarkers Predict Mortality Of Critically Ill Older Patients With Acute Kidney Injury?
Authors Gong Y, Ding F, Gu Y
Received 10 June 2019
Accepted for publication 9 September 2019
Published 18 October 2019 Volume 2019:14 Pages 1763—1769
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Bik-Wai Bilvick Tai
Peer reviewer comments 2
Editor who approved publication: Dr Zhi-Ying Wu
Yu Gong,1 Feng Ding,2 Yong Gu2
1Department of Internal Medicine, Division of Nephrology, Shanghai Municipal Eighth People’s Hospital, Shanghai, People’s Republic of China; 2Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China
Correspondence: Yu Gong
Department of Internal Medicine, Division of Nephrology, Shanghai Municipal Eighth People’s Hospital, 8 Caobao Road, Shanghai 200235, People’s Republic of China
Tel +86 21 18930718612
Background: Critically ill older patients with acute kidney injury (AKI), also referred to as acute renal failure, are associated with high in-hospital mortalities. Preexisting malnutrition is highly prevalent among AKI patients and increases in-hospital mortality rate. This study is to evaluate the predictive power of some serum nutritional related biomarkers predicting the 90 days in-hospital mortality of critically ill older patients with AKI.
Methods: A prospective, observational study was conducted in a university teaching hospital. One hundred and five critically ill older patients with AKI aged 60–95 were enrolled and were divided into survival group (n=44) and non-survival group (n=61) in the light of their final outcomes. Receiver operating characteristic analyses (ROC) were performed to calculate the area under ROC curve (AUC). Sensitivity and specificity of in-hospital mortality prediction were calculated.
Results: Significant differences were found between the survival group and non-survival group of critically ill older patients with AKI. AUC of low density lipoprotein (LDL) and albumin were 0.686 and 0.595, respectively. The asymptotic 95% confidence intervals of LDL and albumin were 0.524–0.820 and 0.488–0.696, respectively. Sensitivity of the 90 days in-hospital mortality prediction of LDL and albumin were 68.71% and 69.09%, respectively. Specificity of 90 days in-hospital mortality prediction of LDL and albumin were 69.23% and 50.0%, respectively.
Conclusion: LDL and albumin did not have sufficient power to predict the 90 days in-hospital mortality of critically ill older patients with AKI. Further research on the association between malnutrition and poor prognosis of critically ill older patients with AKI is needed in the future.
Trial registration: ClinicalTrials.gov identifier: NCT00953992.
Keywords: critically ill older patients, acute kidney injury, mortality, nutritional related biomarker
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]