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Brugada syndrome: updated perspectives

Authors Walia J, Steinberg C, Laksman Z

Received 15 February 2019

Accepted for publication 2 May 2019

Published 4 June 2019 Volume 2019:10 Pages 19—32

DOI https://doi.org/10.2147/RRCC.S182162

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Richard Kones


Jagdeep Walia,1 Christian Steinberg,2 Zachary Laksman1

1Heart Rhythm Services, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada; 2Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Universite Laval, Québec, Canada

Abstract: Since the first reported descriptions of Brugada syndrome, there has been a growing awareness and appreciation of the disease and its implications. From the diagnostic criteria, to risk stratification and management, there is an ongoing evolution, reclassification and re-thinking of Brugada syndrome as basic science, registry and clinical trial data shape our understanding of the pathophysiology and its clinical implications. This in-depth review sheds light on the most important literature to date, highlighting insights that shifted the global perspective on the disease. Current clinical paradigms and guidelines are presented, along with their justification, and possible opportunities for future research are explored.

Keywords: Brugada, risk stratification, sudden death, inherited arrhythmia syndrome


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