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Brittle cornea syndrome: current perspectives

Authors Walkden A, Burkitt-Wright E, Au L

Received 21 May 2019

Accepted for publication 12 July 2019

Published 12 August 2019 Volume 2019:13 Pages 1511—1516

DOI https://doi.org/10.2147/OPTH.S185287

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Nicola Ludin

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Andrew Walkden,1,2 Emma Burkitt-Wright,3,4 Leon Au1,2

1Manchester Royal Eye Hospital, Manchester University Foundation Trust, Manchester, UK; 2Medical Academic Health Sciences Centre, University of Manchester, UK; 3Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK; 4Genetic Medicine, St Mary’s Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK

Abstract: Brittle cornea syndrome (BCS) is a rare autosomal recessive connective tissue disorder characterised by severe corneal thinning, with the major ocular risk being spontaneous ocular perforation due to progressive stromal thinning and ectasia. It is a complex condition with limited treatment options. The purpose of this review is to highlight the difficulties associated with the condition and examine the available published evidence with regards to management.

Keywords: brittle Cornea, spontaneous corneal perforation, corneal ectasia

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