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Bothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes

Authors Luna K, Melo C, Magalhães V, Martins-Filho OA, Pereira VR

Published 26 January 2011 Volume 2011:3 Pages 9—18


Review by Single anonymous peer review

Peer reviewer comments 2

Karla PO Luna1,2, Cristiane ML Melo1, Vanessa P Magalhães3, Olindo A Martins-Filho3, Valéria RA Pereira1
1Departamento de Imunologia, Instituto Aggeu Magalhães – FIOCRUZ, Pernambuco, Brazil; 2Universidade Estadual da Paraíba, Campina Grande, Brazil; 3Centro de Pesquisas René Rachou – FIOCRUZ, Minas Gerais, Brazil

Abstract: Snake venom is a complex biological mixture used for immobilization and killing of prey for alimentation. Many effects are inflicted by this venom, such as coagulation, necrosis, bleeding, inflammation, and shock. This study aimed to evaluate the inflammatory activity promoted by Bothrops erythromelas and Crotalus durissus cascavella snake venom. It was observed that both B. erythromelas and C. d. cascavella venom induced higher interferon-gamma and interleukin-6 production. Nitric oxide (NO) was significantly produced only by B. erythromelas venom, which also showed a higher rate of cell death induction when compared with C. d. cascavella. Results showed that B. erythromelas and C. d. cascavella venom induced distinct response in vitro through cytokines and NO production. However, B. erythromelas induces a proinflammatory response and a higher rate of cell death in relation to C. d. cascavella venom.

Keywords: snake venom, Bothrops, nitric oxide, necrosis, Crotalus

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