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Biomarkers for renal transplantation: where are we?

Authors Ge F, Dai Q, Gong W

Received 27 July 2013

Accepted for publication 3 September 2013

Published 1 October 2013 Volume 2013:6 Pages 187—191

DOI https://doi.org/10.2147/IJNRD.S39806

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5


Fangmin Ge,1–3 Qiaoding Dai,4 Weihua Gong5

1
Hospital Administration Office, 2Department of Medicine, Second Affiliated Hospital Zhejiang University School of Medicine, 3Health Bureau of Shangcheng District Hangzhou, 4Department of Rheumatism and Immunology, First Affiliated Hospital of Zhejiang Chinese Medicine University, 5Department of Surgery, Transplant International Research Centre, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, People's Republic of China

Abstract: Although surgical techniques, post-transplant care medicine, and immunosuppressants have been greatly improved, permanent acceptance of renal allograft remains a clinical challenge owing to the appearance of various influencing factors. To predict graft dysfunction, development of noninvasive biomarkers is becoming a highlighted research topic in the field of renal transplantation, which provides a possibility for physicians to give preemptive rescue treatment. From the viewpoint of diagnostic techniques, repetitive sampling is prerequisite to identify applicable biomarkers in the clinic. Early biomarkers can be used to dynamically monitor renal graft status and accurately predict transplant outcome independent of various confounders. This review highlights recent studies on the predictive value of biomarkers and methods to quantify biomarkers for monitoring kidney transplant. It is important to analyze and compare different biomarkers for living, and nonliving donors. Analysis of identified clinically relevant biomarkers will advance our understanding of distinct molecular and cellular mechanisms of transplantation and provide insight into developing novel potential approaches to induce transplant tolerance.

Keywords: biomarkers, renal transplantation, diagnostic techniques, reversible, preemptive treatment

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