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Bilateral renal artery thrombosis in inherited thrombophilia: a rare cause of acute kidney injury

Authors Wiles K, Hastings L, Muthuppalaniappan V, Hanif M, Abeygunasekara S

Received 3 July 2013

Accepted for publication 22 August 2013

Published 18 January 2014 Volume 2014:7 Pages 35—38


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Kate S Wiles,1 Laura Hastings,1 Vasantha Muthu Muthuppalaniappan,1 Muhammad Hanif,2 Sumith Abeygunasekara1

1Department of Medicine, 2Department of Radiology, Mid Essex Hospital Services NHS Trust, Chelmsford, UK

Abstract: We describe the case of a 47-year-old man who developed significant acute, and subsequently chronic, kidney injury due to bilateral renal infarction. This occurred in the context of a combined inherited thrombophilia including antithrombin III deficiency and a prothrombin gene mutation. Bilateral renal artery thrombosis developed despite prophylactic treatment for thromboembolism. Arterial thrombosis is rare in the context of inherited thrombophilia and bilateral renal infarction is an unusual cause of acute kidney injury. Bilateral renal infarction due to primary renal artery thrombosis has not been previously described in antithrombin III deficiency, either as an isolated defect or in combination with other hereditary thrombophilia.

Keywords: renal infarction, renal thrombosis, AKI, antithrombin, prothrombin

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