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Beneficial response of cervical dystonia spasmodic torticollis to cidofovir, an acyclic phosphonate analog (s-1-3-hydroxy-2- phosphonylmethoxypropyl) of cytosine

Authors Lerner AM, Beqaj S

Received 2 April 2014

Accepted for publication 16 May 2014

Published 16 September 2014 Volume 2014:6 Pages 33—36

DOI https://doi.org/10.2147/VAAT.S65372

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

A Martin Lerner,1 Safedin Beqaj2

1Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA; 2Pathology Inc., Torrance, CA, USA

Abstract: We report the case of a 23-year-old healthy man who had sudden onset of cervical dystonia spasmodic torticollis in October 2012. He was treated with intravenous cidofovir, which was started on February 20, 2013, followed by oral valganciclovir and famciclovir. Pulling of the neck and tilt of the head far to the left is no longer present (as at April 22, 2014). Human herpesvirus 6 total antibody titers fell from 11.27 (negative <1) on January 15, 2013 to 1.89 on August 5, 2013. To our knowledge, this is the first case of improvement in cervical dystonia spasmodic torticollis with treatment.

Keywords: cidofovir, spasmodic torticollis, cervical dystonia

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