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Beneficial effects of training at the anaerobic threshold in addition to pharmacotherapy on weight loss, body composition, and exercise performance in women with obesity

Authors Ozcelik O, Ozkan Y, ALGUL S, COLAK R

Received 10 March 2015

Accepted for publication 21 April 2015

Published 13 July 2015 Volume 2015:9 Pages 999—1004

DOI https://doi.org/10.2147/PPA.S84297

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Johnny Chen

Oguz Ozcelik,1 Yusuf Ozkan,2 Sermin Algul,1 Ramis Colak2,3

1Department of Physiology, 2Department of Endocrinology and Metabolic Disease, Faculty of Medicine, Firat University, Elazig, 3Department of Endocrinology and Metabolic Disease, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey


Objective: The aim of this study was to determine and compare the effects of weight loss achieved through orlistat therapy alone or a combination of orlistat and an aerobic exercise training program on aerobic fitness and body composition in obese females.
Methods: Twenty-eight obese patients were randomly assigned to receive 12-week treatment with hypocaloric diet–orlistat or diet–orlistat–exercise. Each participant performed an incremental ramp exercise test every 4 weeks to measure aerobic fitness. Fourteen participants performed continuous exercise (approximately 45 minutes per session) at a work rate corresponding to the anaerobic threshold three times per week.
Results: A decrease in the fat mass to body weight ratio of 3.8% (P=0.006) was observed at the end of the 12 weeks in the orlistat group, while a decrease of 9.5% (P=0.001) was seen in the orlistat–exercise group. Maximal exercise capacity increased by 46.5% in the orlistat–exercise group and by 19.5% in the orlistat group.
Conclusion: While orlistat therapy resulted in an improvement in body composition and aerobic fitness at the end of the 12-week period, its combination with exercise training provided improvements in the same parameters within the first 4 weeks of the study. These additional beneficial effects of combining aerobic exercise with orlistat therapy are important with regards to obesity-associated risk factors.

Keywords: obesity, orlistat, body mass index, anaerobic threshold, aerobic fitness

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