Original Research

Poloxamer-based binary hydrogels for delivering tramadol hydrochloride: sol-gel transition studies, dissolution-release kinetics, in vitro toxicity, and pharmacological evaluation

dos Santos ACM, Akkari ACS, Ferreira IRS, Maruyama CR, Pascoli M, Guilherme VA, de Paula E, Fraceto LF, de Lima R, Melo PS, de Araujo DR

International Journal of Nanomedicine 2015, 10:2391-2401

Published Date: 25 March 2015