Other papers submitted by: Dr Rafael de Cabo

open access to scientific and medical research

News:

Expressions of interest for Editor-in-Chief - the International Medical Case Reports Journal Read more

Back to User profile » Dr Rafael de Cabo

Papers published by Dr Rafael de Cabo:

Review

Noteworthy comment: This is a well written review on a relevant topic in neuroscience research, specifically the evaluation of nutritional effects on neurodegenerative disease. Since evaluation of behavior and cognition in rodent models underpins mechanistic and interventional studies of brain aging and neurodegenerative diseases, especially dementia, this report is timely. To evaluate the efficacy of nutritional interventions the authors cite commonly used tests such as the Morris water maze, Barnes maze, object recognition, fear conditioning, radial arm water maze and Y maze, which each reflect some aspects of human memory including episodic memory, recognition memory, semantic memory, spatial memory and emotional memory. Referenced studies evaluate a host of nutritional interventions including caloric restriction, intermittent fasting and manipulation of macronutrients. These dietary interventions have been shown to influence various cognitive and behavioral tests in rodents indicating that nutrition can influence brain aging and possibly neurodegeneration.

Highly-accessed

Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia

Wahl D, Coogan SCP, Solon-Biet SM, de Cabo R, Haran JB, Raubenheimer D, Cogger VC, Mattson MP, Simpson SJ, Le Couteur DG

Clinical Interventions in Aging 2017, 12:1419-1428

Published Date: 8 September 2017

Review

Noteworthy comment: This is a very well-written and informative review on the animal tools available for studying frailty and the potentials, and challenges, of translating results to the clinical population. In other words, it bridges the parallel and complementary fields of basic and applied research in gerontology and geriatrics.

Highly-accessed

Animal models of frailty: current applications in clinical research

Kane AE, Hilmer SN, Mach J, Mitchell SJ, de Cabo R, Howlett SE

Clinical Interventions in Aging 2016, 11:1519-1529

Published Date: 26 October 2016