Back to Journals » Clinical, Cosmetic and Investigational Dermatology » Volume 8

Associations between cardiovascular risk factors and psoriasis in Iran

Authors Farshchian M, Ansar A, Sobhan M

Received 10 April 2015

Accepted for publication 8 June 2015

Published 10 August 2015 Volume 2015:8 Pages 437—442

DOI https://doi.org/10.2147/CCID.S86418

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Jeffrey Weinberg

Mahmoud Farshchian, Akram Ansar, Mohammadreza Sobhan

Psoriasis Research Center, Department of Dermatology, Farshchian Hospital, Hamadan University of Medical Sciences, Hamadan, Iran

Background: Psoriasis is a common chronic inflammatory skin disease. There is overwhelming evidence on the higher risk of cardiovascular diseases in patients with psoriasis as a result of hyperlipidemia, which is more common in these patients.
Objectives: The aim of this study was to elucidate the association between the cardiovascular risk factors and psoriasis.
Methods: In a cross-sectional study, 55 patients with psoriasis and 55 matched (sex and age) controls were entered the study at the Department of Dermatology between March 2011 and March 2013. Blood samples were obtained following 14 hours fasting status and serum levels of triglyceride, cholesterol, high-density lipoprotein, and low-density lipoprotein were determined using standard laboratory methods, and other variables such as sex, age, smoking, alcohol consumption, and the type of disease were recorded.
Results: Our findings showed that levels of triglyceride, low-density lipoprotein, and smoking were significantly higher in psoriatic patients when compared with controls, whereas the level of high-density lipoprotein and cholesterol was not significantly different between two groups. Body mass index of psoriatic patients was not significantly higher than controls. Patients with psoriasis also had an increased prevalence of hypertension.
Conclusion: Our findings further verify lipid abnormalities in psoriatic patients. Psoriasis is associated with higher rate of hypertension, which may be resulted in increasing the risk of cardiovascular diseases in these patients. Thus, serum lipid profile and blood pressure in all patients with psoriasis, regardless of disease severity, deserve consideration to be checked.

Keywords: cardiovascular disease, risk factors, psoriasis, lipid profile

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other articles by this author:

Associations between body mass index and severity of psoriasis

Sobhan M, Farshchian M

Clinical, Cosmetic and Investigational Dermatology 2017, 10:493-498

Published Date: 24 November 2017

Spectrum of autoimmune vesiculobullous diseases in Iran: a 13-year retrospective study

Sobhan M, Farshchian M, Tamimi M

Clinical, Cosmetic and Investigational Dermatology 2016, 9:15-20

Published Date: 11 January 2016

Readers of this article also read:

In vitro inhibition of hyaluronidase by sodium copper chlorophyllin complex and chlorophyllin analogs

McCook JP, Dorogi PL, Vasily DB, Cefalo DR

Clinical, Cosmetic and Investigational Dermatology 2015, 8:443-448

Published Date: 10 August 2015

Polycaprolactone/maltodextrin nanocarrier for intracellular drug delivery: formulation, uptake mechanism, internalization kinetics, and subcellular localization

Korang-Yeboah M, Gorantla Y, Paulos SA, Sharma P, Chaudhary J, Palaniappan R

International Journal of Nanomedicine 2015, 10:4763-4781

Published Date: 29 July 2015

Polyetherimide-grafted Fe3O4@SiO2 nanoparticles as theranostic agents for simultaneous VEGF siRNA delivery and magnetic resonance cell imaging

Li T, Shen X, Chen Y, Zhang C, Yan J, Yang H, Wu C, Zeng H, Liu Y

International Journal of Nanomedicine 2015, 10:4279-4291

Published Date: 2 July 2015

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010