Back to Journals » Therapeutics and Clinical Risk Management » Volume 13

Association of uremic pruritus in hemodialysis patients with the number of days of high mean 24-hour particulate matter with a diameter of <2.5 μm

Authors Liu MH, Chan MJ, Hsu CW, Weng CH, Yen TH, Huang WH

Received 1 December 2016

Accepted for publication 19 January 2017

Published 23 February 2017 Volume 2017:13 Pages 255—262

DOI https://doi.org/10.2147/TCRM.S129133

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 4

Editor who approved publication: Professor Deyun Wang

Ming-Hui Liu,1,* Ming-Jen Chan,2,* Ching-Wei Hsu,2,3 Cheng-Hao Weng,2,3 Tzung-Hai Yen,2,3 Wen-Hung Huang2,3

1Department of Pediatric Dentistry, 2Department of Nephrology and Division of Clinical Toxicology and Toxicology Laboratory, Chang Gung Memorial Hospital, Linkou Medical Center, 3Chang Gung University College of Medicine, Taoyuan, Taiwan, Republic of China

*These authors contributed equally to this work

Abstract: Uremic pruritus (UP) is a common and incapacitating symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is multifactorial and complex. Particulate matter (PM), a major air pollutant, is a mixture of particles with various chemical compositions. PM is associated with several allergic diseases, including dermatitis. To assess the role of PM (PM with a diameter of <10 µm [PM10] and PM with a diameter of <2.5 µm [PM2.5]) and other clinical variables in UP in patients on HD, we recruited 866 patients on maintenance HD (MHD). We analyzed the number of days of mean 24-hour PM10 ≥125 µg/m3/12 months (NDPM10) or the number of days of mean 24-hour PM2.5 ≥35 µg/m3/12 months (NDPM2.5) exceeding the standard level in the past 12 months respectively to determine the association with UP. In a multivariate logistic regression, HD duration, serum ferritin levels, low-density lipoprotein (LDL) levels, and NDPM2.5 ≥116 days/12 months were positively associated with UP. This cross-sectional study showed that the number of days on which the environmental PM2.5 exceeds the standard level might be associated with UP in patients on MHD.

Keywords: air pollution, uremic pruritus, environmental particulate matter, PM2.5

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other article by this author:

Positive correlation between environmental PM2.5 and blood lead levels in patients undergoing maintenance hemodialysis

Chen CY, Liu MH, Hsu CW, Weng CH, Yen TH, Huang WH

Therapeutics and Clinical Risk Management 2017, 13:555-564

Published Date: 24 April 2017