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Association of dry eye disease with psychiatric or neurological disorders in elderly patients

Authors Han SB, Yang HK, Hyon JY, Wee WR

Received 21 March 2017

Accepted for publication 10 April 2017

Published 15 May 2017 Volume 2017:12 Pages 785—792

DOI https://doi.org/10.2147/CIA.S137580

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Richard Walker


Sang Beom Han,1 Hee Kyung Yang,2 Joon Young Hyon,2 Won Ryang Wee3

1Department of Ophthalmology, Kangwon National University Hospital, Chuncheon, Gangwon, 2Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, 3Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea


Abstract: Dry eye disease (DED) is a common disease that can impair quality of life significantly. Its prevalence increases with advancing age, and the economic burden of the disease on both a patient and the society is increasing with elongation of life expectancy. The diagnosis and treatment of DED are often difficult due to the discordance between symptoms and signs of the disease. Recent studies have suggested the role of neurological or psychological factors in the development of dry eye symptoms and discrepancy of the symptoms and signs, particularly in elderly patients. In this review, the authors discuss the association of DED with various psychiatric and neurological disorders. In addition to psychiatric conditions, including depression, anxiety, stress, posttraumatic stress disorder and sleep disorders, medications for the psychiatric disorders have association with DED. Neurological disorders, such as neuropathic pain, chronic pain syndrome, peripheral neuropathy and several central nervous system disorders, are related to DED. Treatment of DED, combined with psychiatric or neurological disorders, is also discussed. Attention should be paid to the DED patients with discordant symptoms and signs, and unsatisfactory response to conventional treatment for associated psychiatric or neurological disorders, as well as an integrated treatment approach, could be helpful for these patients.

Keywords: depression, dry eye disease, neurological disorder, neuropathic pain, psychiatric disorders, sleep disorder

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