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Association Between High-Sensitivity Troponin T on Admission and Organ Dysfunction During Hospitalization in Patients Aged 80 Years and Older with Hip Fracture: A Single-Centered Prospective Cohort Study

Authors Qin ZJ, Wu QY, Deng Y, Li X, Wei XD, Tang CJ, Jia JF

Received 22 January 2021

Accepted for publication 12 March 2021

Published 6 April 2021 Volume 2021:16 Pages 583—591

DOI https://doi.org/10.2147/CIA.S303246

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Zhi-Ying Wu


Zhi-Jun Qin,1 Qian-Yun Wu,1 Yang Deng,1 Xia Li,2 Xuan-Di Wei,2 Cheng-Jie Tang,3 Jun-Feng Jia3

1Department of Intensive Care Unit, Sichuan Provincial Orthopedic Hospital, Chengdu, Sichuan, People’s Republic of China; 2Department of General Medicine, Sichuan Provincial Orthopedic Hospital, Chengdu, Sichuan, People’s Republic of China; 3Department of Geriatric Orthopedics, Sichuan Provincial Orthopedic Hospital, Chengdu, Sichuan, People’s Republic of China

Correspondence: Zhi-Jun Qin
Department of Intensive Care Unit, Sichuan Provincial Orthopedic Hospital, No. 132, West First Section, First Ring Road, Chengdu City, Sichuan Province, 610041, People’s Republic of China
Tel +86 − 18728179291
Email [email protected]

Background: Prognostic evaluation of elderly patients with hip fracture is an issue that has been highly concerned by clinicians. Only a few studies have focused on organ dysfunction after hip fracture in the elderly. This study aimed to investigate the association between high-sensitivity troponin T (hs-TnT) at admission and organ dysfunction during hospitalization in elderly patients with hip fracture.
Methods: We enrolled 168 patients with hip fracture who were aged 80 years and older at Geriatric Orthopaedic Center of Sichuan Provincial Orthopedic Hospital between January 2020 and August 2020. Baseline characteristics, perioperative information, and short-term clinical outcomes were analyzed.
Results: Of the 208 patients admitted during the study period, 168 met the inclusion criteria; of these, 91 (54.2%) had higher hs-TnT than the 99th percentile in the normal population. After adjustment for confounders, elevated hs-TnT was independently associated with multiple organ dysfunction syndrome in the elderly (MODSE) (adjusted OR, 5.76; 95% CI, 1.74– 19.10; P = 0.004), heart dysfunction (adjusted OR, 7.48; 95% CI, 2.17– 25.82; P = 0.001), MODS severity score > 3 (adjusted OR, 5.22; 95% CI, 1.32– 20.60; P = 0.018), and length of hospital stay > 14 days (adjusted OR, 2.38; 95% CI, 1.05– 5.36; P = 0.037).
Conclusion: Increased hs-TnT on admission is an independent risk factor for MODSE after hip fracture in patients aged 80 years and older. Effective measures should be applied to avoid progression of MODSE from pre-failure stage to failure stage.

Keywords: high-sensitivity troponin T, hip fracture, multiple organ dysfunction syndrome in the elderly, short-term outcomes

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