Assessment of macrophage migration inhibitory factor in patients with verruca vulgaris
Authors Sorour NE, Hamed AM, Tabl HAEM, Ahmed AAEA
Received 19 March 2019
Accepted for publication 30 July 2019
Published 22 August 2019 Volume 2019:12 Pages 591—595
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Jeffrey Weinberg
Neveen Emad Sorour,1 Ahmed Mohamed Hamed,1 Hala Abd-El Mageed Tabl,2 Amira Abd-El Aziz Ahmed1
1Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha Univesity, Benha, Egypt; 2Department of Medical Microbiology and Immunology, Faculty of Medicine, Benha Univesity, Benha, Egypt
Correspondence: Ahmed Mohamed Hamed
Department of Dermatology, Venereology and Andrology Faculty of Medicine, Benha University, El Kobry street, No.5, Benha 13513, Egypt
Tel +20 0 100 523 9888
Background: Common warts are caused by human papillomaviruses (HPVs), they are among the most common cutaneous viral infections. Macrophage migration inhibitory factor (MIF) is an essential contributor in many inflammatory and immune skin diseases. Yet, its role in the pathology of common warts is unclear.
Objective: To assess MIF levels in lesional and perilesional skin in patients with common warts in comparison to apparently healthy control group with matching age and sex.
Subjects and methods: A case-control study performed on 60 patients with common warts (group A) and 30 age and sex matching healthy controls (group B). Two biopsies were taken from each patient in group A; one from the lesion (lesional) and the other one from the skin around the wart (perilesional), while biopsies of controls were taken from matched sites to patients. Measurement of MIF in all groups was done by quantitative ELISA kits.
Results: Significant high MIF levels were detected in lesional and perilesional skin biopsies compared to controls (P<0.001). Yet, the difference in MIF levels between lesional and perilesional skin biopsy was non-significant. No significant relations were found between lesional and perilesional MIF levels and clinical characteristics of the studied patients while both lesional and perilesional MIF levels were significantly correlated (rh=0.269, P=0.021).
Conclusion: The significantly elevated MIF levels in lesional and perilesional skin biopsies compared to controls point to its role in wart progression from HPV infected cells.
Keywords: macrophage migration inhibitory factor, common warts, human papillomavirus
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]