Back to Browse Journals » Vascular Health and Risk Management » Volume 5

The effect of angiotensin receptor blockers on C-reactive protein and other circulating inflammatory indices in man

Authors Alessandra Del Fiorentino, Silvana Cianchetti, Alessandro Celi, Giulia Dell’Omo, Roberto Pedrinelli

Published 8 February 2009 Volume 2009:5 Pages 233—242


Review by Single-blind

Peer reviewer comments 4

Alessandra Del Fiorentino, Silvana Cianchetti, Alessandro Celi, Giulia Dell’Omo, Roberto Pedrinelli

Dipartimento Cardio Toracico e Vascolare, Università di Pisa, Italy

Abstract: Anti-inflammatory properties may contribute to the pharmacological effects of angiotensin II receptor blockers (ARBs), a leading therapeutic class in the management of hypertension and related cardiovascular and renal diseases. That possibility, supported by consistent evidence from in-vitro and animal studies showing pro-inflammatory properties of angiotensin II, has been evaluated clinically by measuring the effect of ARBs on C-reactive protein and other circulating indices of inflammation (e-selectin, adhesion molecules, interleukin-6, tissue necrosis factor-alpha, monocyte chemoattractant protein-1) of potential clinical relevance, a body of evidence that this paper aims to review.

Keywords: renin–angiotensin system, angiotensin II type 1 receptor blockers, vascular inflammation, C-reactive protein, circulating inflammatory markers

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 


Other article by this author:

Lack of a relationship between circulating gamma-glutamyltransferase levels and carotid intima media thickness in hypertensive and diabetic patients

Nuti M, Spontoni P, Grigoratos C, Dell'Omo G, Balbarini A, Pedrinelli R

Vascular Health and Risk Management 2012, 8:275-281

Published Date: 1 May 2012

Readers of this article also read:

Stem cell tracking using iron oxide nanoparticles

Bull E, Madani SY, Sheth R, Seifalian A, Green M, Seifalian AM

International Journal of Nanomedicine 2014, 9:1641-1653

Published Date: 31 March 2014

Measurement bias between optical coherence tomography instruments can affect access to treatment: a new lottery

Kidess A, El Salloukh A, Dutt P, Keane PA, Tsaloumas MD, Denniston AK

Clinical Ophthalmology 2013, 7:2299-2302

Published Date: 12 December 2013

Small-aperture corneal inlay in patients with prior radial keratotomy surgeries

Huseynova T, Kanamori T, Waring GO IV, Tomita M

Clinical Ophthalmology 2013, 7:1937-1940

Published Date: 26 September 2013

Risky substance exposure during pregnancy: a pilot study from Lebanese mothers

Rachidi S, Awada S, Al-Hajje A, Bawab W, Zein S, Saleh N, Salameh P

Drug, Healthcare and Patient Safety 2013, 5:123-131

Published Date: 15 May 2013

Deposit buildup on prosthetic eye material (in vitro) and its effect on surface wettability

Pine KR, Sloan B, Han KYI, Swift S, Jacobs RJ

Clinical Ophthalmology 2013, 7:313-319

Published Date: 13 February 2013

The association of C3435T single-nucleotide polymorphism, Pgp-glycoprotein gene expression levels and carbamazepine maintenance dose in patients with epilepsy

Sterjev Z, Trencevska GK, Cvetkovska E, Petrov I, Kuzmanovski I, Ribarska JT, Nestorovska AK, Matevska N, Naumovska Z, Jolevska-Trajkovic S, Dimovski A, Suturkova L

Neuropsychiatric Disease and Treatment 2012, 8:191-196

Published Date: 19 April 2012

Central retinal artery occlusion resembling Purtscher-like retinopathy

Kurimoto T, Okamoto N, Oku H, Kanbara Y, Etomi T, Tonari M, Ikeda T

Clinical Ophthalmology 2011, 5:1083-1088

Published Date: 4 August 2011

Cough and asthma diagnosis: physicians’ diagnosis and treatment of patients complaining of acute, subacute and chronic cough in rural areas of Japan

Akira Yamasaki, Keichi Hanaki, Katsuyuki Tomita, et al

International Journal of General Medicine 2010, 3:101-107

Published Date: 3 March 2010

Use of viscoelastic substance in ophthalmic surgery — focus on sodium hyaluronate

Tomomi Higashide, Kazuhisa Sugiyama

Clinical Ophthalmology 2008, 2:21-30

Published Date: 7 March 2008