Back to Browse Journals » Therapeutics and Clinical Risk Management » Volume 4 » Issue 6

Newer treatments for fibromyalgia syndrome

Authors Richard E Harris, Daniel J Clauw

Published 5 December 2008 Volume 2008:4(6) Pages 1331—1342


Review by Single-blind

Peer reviewer comments 5

Richard E Harris, Daniel J Clauw

Department of Anesthesiology, The University of Michigan, Ann Arbor, MI, USA

Abstract: Fibromyalgia syndrome is a common chronic pain disorder of unknown etiology. The lack of understanding of the pathophysiology of fibromyalgia has made this condition frustrating for patients and clinicians alike. The most common symptoms of this disorder are chronic widespread pain, fatigue, sleep disturbances, difficulty with memory, and morning stiffness. Emerging evidence points towards augmented pain processing within the central nervous system (CNS) as having a primary role in the pathophysiology of this disorder. Currently the two drugs that are approved by the United States Food and Drug Administration (FDA) for the management of fibromyalgia are pregabalin and duloxetine. Newer data suggests that milnacipran, a dual norepinephrine and serotonin reuptake inhibitor, may be promising for the treatment of fibromyalgia. A double-blind, placebo-controlled trial of milnacipran in 125 fibromyalgia patients showed significant improvements relative to placebo. Milnacipran given either once or twice daily at doses up to 200 mg/day was generally well tolerated and yielded significant improvements relative to placebo on measures of pain, patient’s global impression of change in their disease state, physical function, and fatigue. Future studies are needed to validate the efficacy of milnacipran in fibromyalgia.

Keywords: fibromyalgia, pain, pharmacological, treatment

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 


Readers of this article also read:

Changes in microarchitectural characteristics at the tibial epiphysis induced by collagen-induced rheumatoid arthritis over time

Lee JH, Chun KJ, Kim HS, Kim SH, Lee K-Y, Kim DJ, Lim D

Clinical Interventions in Aging 2012, 7:373-382

Published Date: 18 September 2012

In vitro evaluation of anticancer nanomedicines based on doxorubicin and amphiphilic Y-shaped copolymers

Li D, Ding JX, Tang ZH, Sun H, Zhuang XL, Xu JZ, Chen XS

International Journal of Nanomedicine 2012, 7:2687-2697

Published Date: 31 May 2012

Challenges for heart disease stem cell therapy

Hoover-Plow J, Gong Y

Vascular Health and Risk Management 2012, 8:99-113

Published Date: 17 February 2012

Clinical utility of the risperidone formulations in the management of schizophrenia

Madaan V, Bestha DP, Kolli VB, Jauhari S, Burket RC

Neuropsychiatric Disease and Treatment 2011, 7:611-620

Published Date: 18 October 2011

Reversal of hepatic fibrosis: pathophysiological basis of antifibrotic therapies

Ismail MH, Pinzani M

Hepatic Medicine: Evidence and Research 2011, 3:69-80

Published Date: 4 July 2011

Potential prescription patterns and errors in elderly adult patients attending public primary health care centers in Mexico City

José Antonio Corona-Rojo, Marina Altagracia-Martínez, Jaime Kravzov-Jinich, et al

Clinical Interventions in Aging 2009, 4:343-350

Published Date: 12 August 2009

Risedronate once monthly: a potential new regimen for the treatment of postmenopausal osteoporosis

María J Moro-Álvarez, Manuel Díaz-Curiel

Clinical Interventions in Aging 2008, 3:227-232

Published Date: 6 June 2008

Cost-effectiveness analysis for trigeminal neuralgia: Cyberknife vs microvascular decompression

Rosanna Tarricone, Giovanni Aguzzi, Francesco Musi, Laura Fariselli, Andrea Casasco

Neuropsychiatric Disease and Treatment 2008, 4:647-652

Published Date: 6 June 2008

The many faces of testosterone

Jerald Bain

Clinical Interventions in Aging 2007, 2:567-576

Published Date: 15 January 2008