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Antioxidant effect of Arabic gum against mercuric chloride-induced nephrotoxicity

Authors Gado AM, Aldahmash BA

Received 2 July 2013

Accepted for publication 2 September 2013

Published 21 October 2013 Volume 2013:7 Pages 1245—1252

DOI https://doi.org/10.2147/DDDT.S50928

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 6


Ali M Gado,1 Badr A Aldahmash2

1Forensic Medicine and Clinical Toxicology Department, College of Medicine, Tanta University, Tanta, Egypt; 2Medical Laboratory Department, College of Health Sciences, King Saud University, Riyadh, Saudi Arabia

Abstract: The effects of Arabic gum (AG) against nephrotoxicity of mercury (Hg), an oxidative-stress inducing substance, in rats were investigated. A single dose of mercuric chloride (5 mg/kg intraperitoneal injection) induced renal toxicity, manifested biochemically by a significant increase in serum creatinine, blood urea nitrogen, thiobarbituric acid reactive substances, and total nitrate/nitrite production in kidney tissues. In addition, reduced glutathione, glutathione peroxidase, and catalase enzymes in renal tissues were significantly decreased. Pretreatment of rats with AG (7.5 g/kg/day per oral administration), starting 5 days before mercuric chloride injection and continuing through the experimental period, resulted in a complete reversal of Hg-induced increase in creatinine, blood urea nitrogen, thiobarbituric acid reactive substances, and total nitrate/nitrite to control values. Histopathologic examination of kidney tissues confirmed the biochemical data; pretreatment of AG prevented Hg-induced degenerative changes of kidney tissues. These results indicate that AG is an efficient cytoprotective agent against Hg-induced nephrotoxicity by a mechanism related at least in part to its ability to decrease oxidative and nitrosative stress and preserve the activity of antioxidant enzymes in kidney tissues.

Keywords: mercury, acacia gum, oxidative stress, lipid per oxidation, kidney toxicity

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