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Antioxidant and hepatoprotective role of gold nanoparticles against murine hepatic schistosomiasis

Authors Dkhil MA, Bauomy AA, Diab MSM, Al-Quraishy S

Received 4 October 2015

Accepted for publication 12 November 2015

Published 16 December 2015 Volume 2015:10(1) Pages 7467—7475

DOI https://doi.org/10.2147/IJN.S97622

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Alexander Kharlamov

Peer reviewer comments 2

Editor who approved publication: Dr Thomas J Webster

Mohamed A Dkhil,1,2 Amira A Bauomy,2,3 Marwa SM Diab,4 Saleh Al-Quraishy2

1Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt; 3Department of Laboratory Sciences, College of Science & Arts, Qassim University, Buraydah, Saudi Arabia; 4Molecular Drug Evaluation Department, National Organization for Drug Control & Research (NODCAR), Giza, Egypt

Abstract: In recent years, gold nanoparticles (AuNPs) have become the focus of much attention in biomedical research, especially in the context of nanomedicine, due to their distinctive physicochemical properties. The current study was planned to assess the effect of three dose levels of AuNPs on the gene expression, histology, and oxidative stress status of Schistosoma mansoni-infected mice liver. Inoculation of mice with 100 µL AuNPs at different doses (0.25, 0.5, and 1 mg/kg mice body weight) twice on day 46 and day 49 postinfection reduced the total worm burden, the egg load in the liver, and the granuloma size. AuNPs also appeared to decrease the activities of malondialdehyde and nitric oxide significantly, and increase the level of glutathione compared to the infected untreated group. Concomitantly, AuNPs ameliorated the inflammatory response by decreasing the mRNA expression of interleukin-1β, interleukin-6, tumor necrosis factor-α, interferon-γ, and inducible nitric oxide synthase. These consistent molecular, histopathological, and biochemical data suggest that AuNPs could ameliorate infection-induced damage in the livers of mice. Our results indicated that AuNPs are effective anti-schistosomal and antioxidant agents. Further confirmation of the role of nanogold as an anti-schistosomal agent, as well as its mechanism of action, requires further studies to be undertaken in the future.

Keywords: nanogold, Schistosoma mansoni, liver, gene expressions, histopathology, oxidative stress, mice

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